Table 1 Patient characteristics, stratified by acute kidney injury status (N = 233)
Patient characteristics | No AKI (n = 73) | AKI (n = 160) | p value |
|---|---|---|---|
Age, median (IQR), year | 66.8 (56.0–80.8) | 72.8 (59.7–81.6) | .21 |
Body mass index, median (IQR), kg/m2 | 25.2 (21.8–28.6) | 27.9 (23.2–33.1) | .01 |
Male sex, No. (%) | 45 (61.6) | 83 (51.9) | .20 |
Pre-admission MAP, median (IQR), mmHga | 83.8 (76.0–91.5) | 78.5 (73.4–87.6) | .05 |
MAP at first hour of admission, median (IQR), mmHg | 67.5 (59.0–78.0) | 65.0 (57.0–73.3) | .1 |
MAP at first hour of resuscitation, median (IQR), mmHg | 62.3 (57.0–73.3) | 63.0 (55.8–70.9) | .2 |
Post-resuscitation MAP, median (IQR), mmHgb | 71.0 (66.0–79.0) | 66.0 (61.0–73.0) | .01 |
ΔMAP from Baseline to 7th hour of resuscitation, median (IQR), mmHgc | 11.0 (0.5–20.3) | 12.4 (5.7–19.8) | .31 |
Charlson comorbidity index, median (IQR) | 6 (4–8.5) | 7 (5–11) | .02 |
APACHE III score, 24 h, median (IQR) | 67 (55.5–79) | 88 (72–103) | .01 |
SOFA score, day 1, median (IQR) | 5 (3–7) | 7 (5–10.8) | .01 |
Culture positive septic shock (%) | 31 (42) | 85 (53) | .2 |
Positive culture source | .7 | ||
Blood (%) | 7 (10) | 20 (13) | |
Urine (%) | 5 (7) | 19 (12) | |
Respiratory (%) | 16 (22) | 33 (20) | |
Wound (%) | 1 (1) | 6 (4) | |
Other (%) | 2 (2) | 7 (4) | |
Culture negative septic shock (%) | 42 (58) | 75 (47) | .2 |
Preexisting condition, No. (%) | |||
Hypertension | 38 (52.1) | 115 (71.9) | .01 |
Myocardial infarction | 10 (13.7) | 39 (24.4) | .08 |
Congestive heart failure | 8 (11.0) | 37 (23.1) | .03 |
Peripheral vascular disease | 3 (4.1) | 25 (15.6) | .02 |
Dementia | 5 (6.8) | 7 (4.4) | .52 |
Cerebrovascular accident | 6 (8.2) | 34 (21.3) | .01 |
Chronic pulmonary disease | 16 (21.9) | 54 (33.8) | .09 |
Rheumatic heart disease | 8 (11.0) | 15 (9.4) | .81 |
Diabetes mellitus | 15 (20.5) | 61 (38.1) | .01 |
Peptic ulcer disease | 6 (8.2) | 20 (12.5) | .38 |
Cirrhosis | 4 (5.5) | 10 (6.3) | > .99 |
Hemiplegia | 4 (5.5) | 3 (1.9) | .21 |
Kidney disease | 10 (13.7) | 45 (28.1) | .02 |
Brittle diabetes mellitus | 4 (5.5) | 26 (16.3) | .02 |
Cancer | 28 (38.4) | 49 (30.6) | .29 |
Leukemia | 1 (1.4) | 9 (5.6) | .18 |
Lymphoma | 2 (2.7) | 8 (5.0) | .73 |
Moderate or severe liver disease | 3 (4.1) | 5 (3.1) | .71 |
Metastatic cancer | 7 (9.6) | 14 (8.8) | .81 |
Any inotropic agent, No. (%) | 4 (5.5) | 28 (17.5) | .01 |
Any vasoactive agent, No. (%) | 32 (43.8) | 108 (67.5) | .01 |
Fluid balance, median (IQR), mL | 4945 (2019–8282) | 6948 (3658–10,810) | .01 |