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Table 1 Patient characteristics, stratified by acute kidney injury status (N = 233)

From: Impact of individualized target mean arterial pressure for septic shock resuscitation on the incidence of acute kidney injury: a retrospective cohort study

Patient characteristics No AKI (n = 73) AKI (n = 160) p value
Age, median (IQR), year 66.8 (56.0–80.8) 72.8 (59.7–81.6) .21
Body mass index, median (IQR), kg/m2 25.2 (21.8–28.6) 27.9 (23.2–33.1) .01
Male sex, No. (%) 45 (61.6) 83 (51.9) .20
Pre-admission MAP, median (IQR), mmHga 83.8 (76.0–91.5) 78.5 (73.4–87.6) .05
MAP at first hour of admission, median (IQR), mmHg 67.5 (59.0–78.0) 65.0 (57.0–73.3) .1
MAP at first hour of resuscitation, median (IQR), mmHg 62.3 (57.0–73.3) 63.0 (55.8–70.9) .2
Post-resuscitation MAP, median (IQR), mmHgb 71.0 (66.0–79.0) 66.0 (61.0–73.0) .01
ΔMAP from Baseline to 7th hour of resuscitation, median (IQR), mmHgc 11.0 (0.5–20.3) 12.4 (5.7–19.8) .31
Charlson comorbidity index, median (IQR) 6 (4–8.5) 7 (5–11) .02
APACHE III score, 24 h, median (IQR) 67 (55.5–79) 88 (72–103) .01
SOFA score, day 1, median (IQR) 5 (3–7) 7 (5–10.8) .01
Culture positive septic shock (%) 31 (42) 85 (53) .2
Positive culture source .7
 Blood (%) 7 (10) 20 (13)  
 Urine (%) 5 (7) 19 (12)  
 Respiratory (%) 16 (22) 33 (20)  
 Wound (%) 1 (1) 6 (4)  
 Other (%) 2 (2) 7 (4)  
Culture negative septic shock (%) 42 (58) 75 (47) .2
Preexisting condition, No. (%)  
 Hypertension 38 (52.1) 115 (71.9) .01
  Myocardial infarction 10 (13.7) 39 (24.4) .08
  Congestive heart failure 8 (11.0) 37 (23.1) .03
  Peripheral vascular disease 3 (4.1) 25 (15.6) .02
  Dementia 5 (6.8) 7 (4.4) .52
  Cerebrovascular accident 6 (8.2) 34 (21.3) .01
  Chronic pulmonary disease 16 (21.9) 54 (33.8) .09
  Rheumatic heart disease 8 (11.0) 15 (9.4) .81
  Diabetes mellitus 15 (20.5) 61 (38.1) .01
  Peptic ulcer disease 6 (8.2) 20 (12.5) .38
  Cirrhosis 4 (5.5) 10 (6.3) > .99
  Hemiplegia 4 (5.5) 3 (1.9) .21
  Kidney disease 10 (13.7) 45 (28.1) .02
  Brittle diabetes mellitus 4 (5.5) 26 (16.3) .02
  Cancer 28 (38.4) 49 (30.6) .29
  Leukemia 1 (1.4) 9 (5.6) .18
  Lymphoma 2 (2.7) 8 (5.0) .73
  Moderate or severe liver disease 3 (4.1) 5 (3.1) .71
  Metastatic cancer 7 (9.6) 14 (8.8) .81
  Any inotropic agent, No. (%) 4 (5.5) 28 (17.5) .01
 Any vasoactive agent, No. (%) 32 (43.8) 108 (67.5) .01
 Fluid balance, median (IQR), mL 4945 (2019–8282) 6948 (3658–10,810) .01
  1. APACHE acute physiology, age, chronic health evaluation, MAP mean arterial pressure, SOFA sequential organ failure assessment
  2. aFrom noninvasive blood pressure monitoring
  3. bSeventh hour of early goal-directed therapy
  4. cDefined as pre-admission minus post-resuscitation MAP