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Table 2 Comparison of patients in quartile 1 versus quartiles 2–4 of delta mean arterial pressure (N = 233)

From: Impact of individualized target mean arterial pressure for septic shock resuscitation on the incidence of acute kidney injury: a retrospective cohort study

Characteristic Quartile 1 (n = 58) Quartiles 2–4 (n = 175) p value
Age, median (IQR), year 66.3 (55.7–79.9) 72.1 (59.4–81.7) .60
Body mass index, median (IQR), kg/m2 27.8 (23.7–32.8) 26.8 (22.2–31.6) .23
Male sex, No. (%) 32 (55.2) 96 (54.9) > .99
Pre-admission MAP, median (IQR), mmHga 73.9 (67.8–81.9) 82.0 (76.3–91.0) .01
Post-resuscitation MAP, median (IQR), mmHgb 79.0 (70.5–87.1) 66.0 (61.0–71.0) .01
Acute kidney injury, No. (%) 33 (56.9) 127 (72.6) .03
 Stage 1 13 (17.8) 60 (82.2)  
 Stage 2 14 (26.0) 40 (74.1)  
 Stage 3 6 (18.2) 27 (81.8)  
Charlson comorbidity index, median (IQR) 7 (4.8–10.3) 7 (5.0–10.0) .55
APACHE III score, 24 h, median (IQR) 78 (64.8–97.3) 82 (66–97) .66
SOFA score, day 1, median (IQR) 6 (4–9) 7 (4–10) .76
Culture positive septic shock (%) 29 (50) 87 (50) .96
Positive culture source .5
 Blood (%) 5 (9) 22 (13)  
 Urine (%) 5 (9) 19 (11)  
 Respiratory (%) 16 (28) 33 (19)  
 Wound (%) 2 (3) 5 (3)  
 Other (%) 1 (1) 8 (4)  
Culture negative septic shock (%) 29 (50) 88 (50) .96
Preexisting condition, No. (%)  
 Hypertension 36 (62.1) 117 (66.9) .53
 Myocardial infarction 11 (19.0) 38 (21.7) .71
 Congestive heart failure 16 (27.6) 29 (16.6) .08
 Peripheral vascular disease 5 (8.6) 23 (13.1) .49
 Dementia 0 (0) 12 (6.9) .04
 Cerebrovascular accident 9 (15.5) 31 (17.7) .84
 Chronic pulmonary disease 16 (27.6) 54 (30.9) .74
 Rheumatic heart disease 7 (12.1) 16 (9.1) .61
 Diabetes mellitus 22 (37.9) 54 (30.9) .34
 Peptic ulcer disease 7 (12.1) 19 (10.9) .81
 Cirrhosis 2 (3.4) 12 (6.9) .53
 Hemiplegia 5 (8.6) 2 (1.1) .01
 Kidney disease 14 (24.1) 41 (23.4) > .99
 Brittle diabetes mellitus 7 (12.1) 23 (13.1) > .99
 Cancer 19 (32.8) 58 (33.1) > .99
 Leukemia 3 (5.2) 7 (4.0) .71
 Lymphoma 7 (12.1) 3 (1.7) .01
 Moderate or severe liver disease 2 (3.4) 6 (3.4) > .99
 Metastatic cancer 6 (10.3) 15 (8.6) .79
Any inotropic agent, No. (%) 5 (8.6) 27 (15.4) .27
Any vasoactive agent, No. (%) 35 (60.3) 105 (60.0) > .99
Fluid balance, median (IQR), mL 6405 (2141–9723) 6102 (3210–9742) .31
  1. APACHE acute physiology, age, chronic health evaluation, MAP mean arterial pressure, SOFA Sequential organ failure assessment
  2. aFrom noninvasive blood pressure monitoring
  3. bSeventh hour of early goal-directed therapy