Table 2 Comparison of patients in quartile 1 versus quartiles 2–4 of delta mean arterial pressure (N = 233)
Characteristic | Quartile 1 (n = 58) | Quartiles 2–4 (n = 175) | p value |
|---|---|---|---|
Age, median (IQR), year | 66.3 (55.7–79.9) | 72.1 (59.4–81.7) | .60 |
Body mass index, median (IQR), kg/m2 | 27.8 (23.7–32.8) | 26.8 (22.2–31.6) | .23 |
Male sex, No. (%) | 32 (55.2) | 96 (54.9) | > .99 |
Pre-admission MAP, median (IQR), mmHga | 73.9 (67.8–81.9) | 82.0 (76.3–91.0) | .01 |
Post-resuscitation MAP, median (IQR), mmHgb | 79.0 (70.5–87.1) | 66.0 (61.0–71.0) | .01 |
Acute kidney injury, No. (%) | 33 (56.9) | 127 (72.6) | .03 |
Stage 1 | 13 (17.8) | 60 (82.2) | |
Stage 2 | 14 (26.0) | 40 (74.1) | |
Stage 3 | 6 (18.2) | 27 (81.8) | |
Charlson comorbidity index, median (IQR) | 7 (4.8–10.3) | 7 (5.0–10.0) | .55 |
APACHE III score, 24 h, median (IQR) | 78 (64.8–97.3) | 82 (66–97) | .66 |
SOFA score, day 1, median (IQR) | 6 (4–9) | 7 (4–10) | .76 |
Culture positive septic shock (%) | 29 (50) | 87 (50) | .96 |
Positive culture source | .5 | ||
Blood (%) | 5 (9) | 22 (13) | |
Urine (%) | 5 (9) | 19 (11) | |
Respiratory (%) | 16 (28) | 33 (19) | |
Wound (%) | 2 (3) | 5 (3) | |
Other (%) | 1 (1) | 8 (4) | |
Culture negative septic shock (%) | 29 (50) | 88 (50) | .96 |
Preexisting condition, No. (%) | |||
Hypertension | 36 (62.1) | 117 (66.9) | .53 |
Myocardial infarction | 11 (19.0) | 38 (21.7) | .71 |
Congestive heart failure | 16 (27.6) | 29 (16.6) | .08 |
Peripheral vascular disease | 5 (8.6) | 23 (13.1) | .49 |
Dementia | 0 (0) | 12 (6.9) | .04 |
Cerebrovascular accident | 9 (15.5) | 31 (17.7) | .84 |
Chronic pulmonary disease | 16 (27.6) | 54 (30.9) | .74 |
Rheumatic heart disease | 7 (12.1) | 16 (9.1) | .61 |
Diabetes mellitus | 22 (37.9) | 54 (30.9) | .34 |
Peptic ulcer disease | 7 (12.1) | 19 (10.9) | .81 |
Cirrhosis | 2 (3.4) | 12 (6.9) | .53 |
Hemiplegia | 5 (8.6) | 2 (1.1) | .01 |
Kidney disease | 14 (24.1) | 41 (23.4) | > .99 |
Brittle diabetes mellitus | 7 (12.1) | 23 (13.1) | > .99 |
Cancer | 19 (32.8) | 58 (33.1) | > .99 |
Leukemia | 3 (5.2) | 7 (4.0) | .71 |
Lymphoma | 7 (12.1) | 3 (1.7) | .01 |
Moderate or severe liver disease | 2 (3.4) | 6 (3.4) | > .99 |
Metastatic cancer | 6 (10.3) | 15 (8.6) | .79 |
Any inotropic agent, No. (%) | 5 (8.6) | 27 (15.4) | .27 |
Any vasoactive agent, No. (%) | 35 (60.3) | 105 (60.0) | > .99 |
Fluid balance, median (IQR), mL | 6405 (2141–9723) | 6102 (3210–9742) | .31 |