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Table 5 Comparison of patients with hypertension in quartile 1 versus quartiles 2–4 of delta mean arterial pressure (n = 153)

From: Impact of individualized target mean arterial pressure for septic shock resuscitation on the incidence of acute kidney injury: a retrospective cohort study

Characteristic First quartile (n = 39) Second to fourth quartiles (n = 114) p value
Age, median (IQR), year 73.7 (55.9–80.7) 74.8 (64.2–83.1) .14
Body mass index, median (IQR), kg/m2 28.6 (23.9–34.1) 27.9 (23.3–33.6) .39
Male sex, No. (%) 22 (56.4) 61 (53.5) .85
Pre-admission MAP, median (IQR), mmHga 75.0 (69.0–84.0) 83.5 (76.7–91.3) .01
Post-resuscitation MAP, median (IQR), mmHgb 79.0 (71.5–86.0) 65.0 (61.0–70.3) .01
Acute kidney injury, No. (%) 24 (61.5) 91 (79.8) .03
 Stage 1 9 (18.8) 39 (81.3)  
 Stage 2 10 (23.8) 32 (76.2)  
 Stage 3 5 (20.0) 20 (80.0)  
Charlson comorbidity index, median (IQR) 9 (6–12) 7.5 (6–11) .62
APACHE III score, day 1, median (IQR) 88 (72–99) 85.5 (68.8–104.3) .51
SOFA score, day 1, median (IQR) 6 (4–8) 7 (4–10) .28
Preexisting condition, No. (%)  
 Myocardial infarction 10 (25.6) 31 (27.2) > .99
 Congestive heart failure 14 (35.9) 25 (21.9) .09
 Peripheral vascular disease 5 (12.8) 22 (19.3) .47
 Dementia 0 (0) 10 (8.8) .07
 Cerebrovascular accident 8 (20.5) 28 (24.6) .67
 Chronic pulmonary disease 12 (30.8) 40 (35.1) .70
 Rheumatic heart disease 6 (15.4) 10 (8.8) .24
 Diabetes mellitus 18 (46.2) 48 (42.1) .71
 Peptic ulcer disease 6 (15.4) 18 (15.8) > .99
 Cirrhosis 0 (0) 8 (7.0) .20
 Hemiplegia 5 (12.8) 2 (1.8) .01
 Kidney disease 13 (33.3) 35 (30.7) .84
 Brittle diabetes mellitus 7 (17.9) 20 (17.5) > .99
 Cancer 15 (38.5) 36 (31.6) .44
 Leukemia 2 (5.1) 4 (3.5) .65
 Lymphoma 4 (10.3) 3 (2.6) .07
 Moderate or severe liver disease 0 (0) 4 (3.5) .57
 Metastatic cancer 5 (12.8) 10 (8.8) .53
Any inotropic agent, No. (%) 3 (7.7) 21 (18.4) .13
Any vasoactive agent, No. (%) 24 (61.5) 70 (61.4) > .99
Fluid balance, median (IQR), mL 7193 (1349–10,280) 5733 (2820–10,220) .32
  1. ΔMAP is defined as pre-admission minus post-resuscitation MAP
  2. APACHE acute physiology, age, chronic health evaluation, MAP mean arterial pressure, SOFA sequential organ failure assessment
  3. aFrom noninvasive blood pressure monitoring
  4. bSeventh hour of early goal-directed therapy