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Table 1 Demographic characteristics and mechanical ventilation variables from randomized and surviving ARDS patients

From: Driving pressure and long-term outcomes in moderate/severe acute respiratory distress syndrome

Characteristics

Randomized patients (N = 33)

Surviving patients (N = 22)

Nonsurviving patients (n = 11)

P value

Age, year

49 ± 14.9

48.5 ± 13.9

50 ± 16.7

0.80

Sex, % male

22 (66.7)

15 (68)

7 (46.7)

1.00

Smokers (%)

10 (30)

7 (28)

3 (27)

1.00

Origin of ARDS

 Primary N, %

23 (70)

17 (77)

6 (55)

0.24

 Secondary N, %

10 (30)

5 (23)

5 (45)

 

Baseline data

 APACHE II

19.6 ± 10.5

17.1 ± 5.3

24.5 ± 16.0

0.16

 P/F ratio

129 ± 32

135 ± 34

118 ± 23

0.09

 Tidal volume, mL/kg PBW

5.9 (5.7–6.0)

5.9 (5.5–6.0)

5.9 (5.9–6.4)

0.78

 Driving pressure, cmH2O

13.5 ± 4

13.2 ± 3.9

14.1 ± 4.3

0.58

 Plateau pressure, cmH2O

25.4 ± 3.8

25.3 ± 4.2

25.6 ± 3.3

1.00

 PEEP, cmH2O

10 (10–14)

10 (10–14)

10 (10–13)

0.69

 Cstat, mL/cmH2O/kg PBW

0.48 ± 0.15

0.47 ± 0.15

0.50 ± 0.16

0.69

Data 24 h after inclusion

 OLA arm patients, %

18 (54%)

11(50%)

7 (63%)

0.71

 P/F ratio

173 ± 62

174 ± 57

170 ± 70

0.96

 Tidal volume, mL/PBW

5.3 ± 1.1

5.5 ± 0.9

4.9 ± 1.4

0.20

 Driving pressure, cmH2O

11 (10–14)

11 (10–14)

12 (10–12.5)

0.92

 Plateau pressure, cmH2O

28 (26–30)

27.5 (26.2–30)

30 (24.5–31)

0.48

 PEEP, cmH2O

15.4 ± 5.1

15.3 ± 4.9

15.5 ± 5.5

0.93

 Cstat, mL/cmH2O/kg PBW

0.44 (0.40–0.53)

0.45 (0.41–0.54)

0.43 (0.37–0.47)

0.19

 Days of ventilator use

9 (6.5–13.5)

9 (6.2–11.7)

12 (10–14.5)

0.14

 ICU length of stay, days

16 (11.7–24)

18.5 (12–24.7)

15 (12.5–17)

0.26

 Hosp. length of stay, days

27.5 (16.7–56.7)

34 (20.7–73.5)

21 (15–25)

0.02

  1. Parametric data are presented as mean ± 1 standard deviation or median (first and third quartiles)
  2. P/F ratio PaO2/FIO2 ratio, PBW predicted body weight and Cstat static compliance