From: Driving pressure and long-term outcomes in moderate/severe acute respiratory distress syndrome
Characteristics | Randomized patients (N = 33) | Surviving patients (N = 22) | Nonsurviving patients (n = 11) | P value |
---|---|---|---|---|
Age, year | 49 ± 14.9 | 48.5 ± 13.9 | 50 ± 16.7 | 0.80 |
Sex, % male | 22 (66.7) | 15 (68) | 7 (46.7) | 1.00 |
Smokers (%) | 10 (30) | 7 (28) | 3 (27) | 1.00 |
Origin of ARDS | ||||
Primary N, % | 23 (70) | 17 (77) | 6 (55) | 0.24 |
Secondary N, % | 10 (30) | 5 (23) | 5 (45) | |
Baseline data | ||||
APACHE II | 19.6 ± 10.5 | 17.1 ± 5.3 | 24.5 ± 16.0 | 0.16 |
P/F ratio | 129 ± 32 | 135 ± 34 | 118 ± 23 | 0.09 |
Tidal volume, mL/kg PBW | 5.9 (5.7–6.0) | 5.9 (5.5–6.0) | 5.9 (5.9–6.4) | 0.78 |
Driving pressure, cmH2O | 13.5 ± 4 | 13.2 ± 3.9 | 14.1 ± 4.3 | 0.58 |
Plateau pressure, cmH2O | 25.4 ± 3.8 | 25.3 ± 4.2 | 25.6 ± 3.3 | 1.00 |
PEEP, cmH2O | 10 (10–14) | 10 (10–14) | 10 (10–13) | 0.69 |
Cstat, mL/cmH2O/kg PBW | 0.48 ± 0.15 | 0.47 ± 0.15 | 0.50 ± 0.16 | 0.69 |
Data 24 h after inclusion | ||||
OLA arm patients, % | 18 (54%) | 11(50%) | 7 (63%) | 0.71 |
P/F ratio | 173 ± 62 | 174 ± 57 | 170 ± 70 | 0.96 |
Tidal volume, mL/PBW | 5.3 ± 1.1 | 5.5 ± 0.9 | 4.9 ± 1.4 | 0.20 |
Driving pressure, cmH2O | 11 (10–14) | 11 (10–14) | 12 (10–12.5) | 0.92 |
Plateau pressure, cmH2O | 28 (26–30) | 27.5 (26.2–30) | 30 (24.5–31) | 0.48 |
PEEP, cmH2O | 15.4 ± 5.1 | 15.3 ± 4.9 | 15.5 ± 5.5 | 0.93 |
Cstat, mL/cmH2O/kg PBW | 0.44 (0.40–0.53) | 0.45 (0.41–0.54) | 0.43 (0.37–0.47) | 0.19 |
Days of ventilator use | 9 (6.5–13.5) | 9 (6.2–11.7) | 12 (10–14.5) | 0.14 |
ICU length of stay, days | 16 (11.7–24) | 18.5 (12–24.7) | 15 (12.5–17) | 0.26 |
Hosp. length of stay, days | 27.5 (16.7–56.7) | 34 (20.7–73.5) | 21 (15–25) | 0.02 |