Skip to main content

Table 2 Spirometry, plethysmography and volumetric capnography results

From: Nasal high-flow bronchodilator nebulization: a randomized cross-over study

 

Standard-nebulisation

NHF-nebulization

Control-NHF

Before

After

Individual change

Before

After

Individual change

Before

After

Individual change

FEV1 (L)

1.77

(1.43; 2.16)

2.20

(1.69; 2.47)

0.350 (0.180; 0.550)*

18% (8; 30)*

1.77

(1.47; 2.27)

2.14

(1.71; 2.41)

0.330 (0.140; 0.390)*

16% (5; 24)*

1.83

(1.36; 2.42)

1.93

(1.27; 2.52)

0.050 (− 0.010; 0.220)*

3% (− 1; 8)*

Functional residual capacity (L)

4.58

(3.89; 5.22)

4.07

(3.42; 4.88)

− 0.33

(− 0.71; − 0.17)*

4.42

(3.67; 5.35)

4.04

(3.45; 5.09)

− 0.40

(− 0.64; − 0.12)*

4.58

(3.80; 5.38)

4.42

(3.72; 5.53)

− 0.02

(− 0.24; 0.10)

Residual volume (L)

3.42

(2.63; 4.22)

2.89

(2.42; 3.54)

− 0.37

(− 0.82; − 0.12)*

3.22

(2.53; 4.29)

2.90

(2.52; 4.20)

− 0.34

(− 0.64; − 0.06)*

3.27

(2.76; 3.99)

3.19

(2.72; 4.56)

− 0.09

(− 0.34; 0.16)

Forced vital capacity (L)

3.57

(2.66; 4.39)

3.65

(3.15; 4.59)

0.32

(0.08; 0.57)*

3.41

(2.79; 4.37)

3.51

(3.05; 4.47)

0.11

(0.00; 0.34)*

3.28

(2.74; 4.52)

3.58

(2.64; 4.42)

0.10

(− 0.10; 0.25)

Plethysmographic airway resistances (raw)

5.31

(3.72; 6.94)

2.89

(2.54; 3.80)

− 2.06

(− 3.82; − 0.96)*

4.62

(3.48; 7.27)

3.10

(2.39; 3.79)

− 1.89

(− 3.36; − 0.69)*

4.71

(3.22; 7.02)

4.64

(2.86; 5.77)

− 0.39

(− 1.02; 0.04)*

Inspiratory capacity (L)

2.36

(2.03; 2.71)

2.63 (2.26; 3.34)

0.30

(0.14; 0.54)*

2.59

(2.12; 2.90)

2.72

(2.17; 3.17)

0.20

(0.05; 0.47)*

2.21

(1.78; 2.97)

2.61

(1.93; 2.91)

0.10

(− 0.07; 0.20)

Part III of the volumetric capnography slope (n = 16)

0.56

(0.47; 0.74)

0.66

(0.51; 0.92)

0.04

(− 0.03; 0.13)

0.67

(0.41; 0.94)

0.64

(0.40; 0.98)

0.03

(− 0.11; 0.08)

0.62

(0.47; 0.89)

0.65

(0.45; 0.91)

0.01

(− 0.05; 0.12)

  1. Standard-nebulization consisted in 2.5 mg albuterol delivery with a jet nebulizer connected to an aerosol facial mask; NHF-nebulization: 2.5 mg albuterol delivered within a nasal high-flow (NHF) circuit; Control-NHF: nasal high flow without nebulization
  2. FEV1 forced expiratory volume in one second, NHF nasal high-flow
  3. *p < 0.05 for individual changes before and after each session with one technique