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Table 2 Spirometry, plethysmography and volumetric capnography results

From: Nasal high-flow bronchodilator nebulization: a randomized cross-over study

  Standard-nebulisation NHF-nebulization Control-NHF
Before After Individual change Before After Individual change Before After Individual change
FEV1 (L) 1.77
(1.43; 2.16)
2.20
(1.69; 2.47)
0.350 (0.180; 0.550)*
18% (8; 30)*
1.77
(1.47; 2.27)
2.14
(1.71; 2.41)
0.330 (0.140; 0.390)*
16% (5; 24)*
1.83
(1.36; 2.42)
1.93
(1.27; 2.52)
0.050 (− 0.010; 0.220)*
3% (− 1; 8)*
Functional residual capacity (L) 4.58
(3.89; 5.22)
4.07
(3.42; 4.88)
− 0.33
(− 0.71; − 0.17)*
4.42
(3.67; 5.35)
4.04
(3.45; 5.09)
− 0.40
(− 0.64; − 0.12)*
4.58
(3.80; 5.38)
4.42
(3.72; 5.53)
− 0.02
(− 0.24; 0.10)
Residual volume (L) 3.42
(2.63; 4.22)
2.89
(2.42; 3.54)
− 0.37
(− 0.82; − 0.12)*
3.22
(2.53; 4.29)
2.90
(2.52; 4.20)
− 0.34
(− 0.64; − 0.06)*
3.27
(2.76; 3.99)
3.19
(2.72; 4.56)
− 0.09
(− 0.34; 0.16)
Forced vital capacity (L) 3.57
(2.66; 4.39)
3.65
(3.15; 4.59)
0.32
(0.08; 0.57)*
3.41
(2.79; 4.37)
3.51
(3.05; 4.47)
0.11
(0.00; 0.34)*
3.28
(2.74; 4.52)
3.58
(2.64; 4.42)
0.10
(− 0.10; 0.25)
Plethysmographic airway resistances (raw) 5.31
(3.72; 6.94)
2.89
(2.54; 3.80)
− 2.06
(− 3.82; − 0.96)*
4.62
(3.48; 7.27)
3.10
(2.39; 3.79)
− 1.89
(− 3.36; − 0.69)*
4.71
(3.22; 7.02)
4.64
(2.86; 5.77)
− 0.39
(− 1.02; 0.04)*
Inspiratory capacity (L) 2.36
(2.03; 2.71)
2.63 (2.26; 3.34) 0.30
(0.14; 0.54)*
2.59
(2.12; 2.90)
2.72
(2.17; 3.17)
0.20
(0.05; 0.47)*
2.21
(1.78; 2.97)
2.61
(1.93; 2.91)
0.10
(− 0.07; 0.20)
Part III of the volumetric capnography slope (n = 16) 0.56
(0.47; 0.74)
0.66
(0.51; 0.92)
0.04
(− 0.03; 0.13)
0.67
(0.41; 0.94)
0.64
(0.40; 0.98)
0.03
(− 0.11; 0.08)
0.62
(0.47; 0.89)
0.65
(0.45; 0.91)
0.01
(− 0.05; 0.12)
  1. Standard-nebulization consisted in 2.5 mg albuterol delivery with a jet nebulizer connected to an aerosol facial mask; NHF-nebulization: 2.5 mg albuterol delivered within a nasal high-flow (NHF) circuit; Control-NHF: nasal high flow without nebulization
  2. FEV1 forced expiratory volume in one second, NHF nasal high-flow
  3. *p < 0.05 for individual changes before and after each session with one technique