From: Nasal high-flow bronchodilator nebulization: a randomized cross-over study
Standard-nebulisation | NHF-nebulization | Control-NHF | |||||||
---|---|---|---|---|---|---|---|---|---|
Before | After | Individual change | Before | After | Individual change | Before | After | Individual change | |
FEV1 (L) | 1.77 (1.43; 2.16) | 2.20 (1.69; 2.47) | 0.350 (0.180; 0.550)* 18% (8; 30)* | 1.77 (1.47; 2.27) | 2.14 (1.71; 2.41) | 0.330 (0.140; 0.390)* 16% (5; 24)* | 1.83 (1.36; 2.42) | 1.93 (1.27; 2.52) | 0.050 (− 0.010; 0.220)* 3% (− 1; 8)* |
Functional residual capacity (L) | 4.58 (3.89; 5.22) | 4.07 (3.42; 4.88) | − 0.33 (− 0.71; − 0.17)* | 4.42 (3.67; 5.35) | 4.04 (3.45; 5.09) | − 0.40 (− 0.64; − 0.12)* | 4.58 (3.80; 5.38) | 4.42 (3.72; 5.53) | − 0.02 (− 0.24; 0.10) |
Residual volume (L) | 3.42 (2.63; 4.22) | 2.89 (2.42; 3.54) | − 0.37 (− 0.82; − 0.12)* | 3.22 (2.53; 4.29) | 2.90 (2.52; 4.20) | − 0.34 (− 0.64; − 0.06)* | 3.27 (2.76; 3.99) | 3.19 (2.72; 4.56) | − 0.09 (− 0.34; 0.16) |
Forced vital capacity (L) | 3.57 (2.66; 4.39) | 3.65 (3.15; 4.59) | 0.32 (0.08; 0.57)* | 3.41 (2.79; 4.37) | 3.51 (3.05; 4.47) | 0.11 (0.00; 0.34)* | 3.28 (2.74; 4.52) | 3.58 (2.64; 4.42) | 0.10 (− 0.10; 0.25) |
Plethysmographic airway resistances (raw) | 5.31 (3.72; 6.94) | 2.89 (2.54; 3.80) | − 2.06 (− 3.82; − 0.96)* | 4.62 (3.48; 7.27) | 3.10 (2.39; 3.79) | − 1.89 (− 3.36; − 0.69)* | 4.71 (3.22; 7.02) | 4.64 (2.86; 5.77) | − 0.39 (− 1.02; 0.04)* |
Inspiratory capacity (L) | 2.36 (2.03; 2.71) | 2.63 (2.26; 3.34) | 0.30 (0.14; 0.54)* | 2.59 (2.12; 2.90) | 2.72 (2.17; 3.17) | 0.20 (0.05; 0.47)* | 2.21 (1.78; 2.97) | 2.61 (1.93; 2.91) | 0.10 (− 0.07; 0.20) |
Part III of the volumetric capnography slope (n = 16) | 0.56 (0.47; 0.74) | 0.66 (0.51; 0.92) | 0.04 (− 0.03; 0.13) | 0.67 (0.41; 0.94) | 0.64 (0.40; 0.98) | 0.03 (− 0.11; 0.08) | 0.62 (0.47; 0.89) | 0.65 (0.45; 0.91) | 0.01 (− 0.05; 0.12) |