Table 3 Univariable and multivariable analyses of factors associated with ischemic stroke on VA-ECMO
From: Ischemic and hemorrhagic brain injury during venoarterial-extracorporeal membrane oxygenation
Factor | Univariable analysis | Multivariable analysis | ||
|---|---|---|---|---|
OR [95% CI] | P value | OR [95% CI] | P value | |
Age > 53 years | 0.8 [0.4–1.5] | 0.5 | ||
Female sex | 0.97 [0.5–1.9] | 1 | ||
SAPS II score at ICU admission ≥ 72 | 0.69 [0.4–1.3] | 0.3 | ||
Renal replacement therapy | 1.6 [0.7–3.4] | 0.4 | ||
Intra-aortic balloon pump | 1.13 [0.59–2.16] | 0.7 | ||
Central VA-ECMO | 2.8 [1.4–5.5] | 0.004 | 3.2 [1.5–6.6] | 0.002 |
Post-cardiac surgery | 2.2 [1.2–4.1] | 0.01 | ||
Blood tests at ECMO initiation | ||||
Lactate > 6 mmol/L | 1.0 [0.5–1.9] | 1 | ||
pH < 7.32 | 1.1 [0.6–2.1] | 0.9 | ||
Platelets > 350 giga/L | 3.7 [1.3–10.0] | 0.02 | 3.8 [1.4–10.7] | 0.01 |
Bilirubin > 20 µmol/L | 0.8 [0.4–1.5] | 0.5 | ||
Fibrinogen > 6 g/L | 1.8 [0.7–5.0] | 0.2 | ||
Prothrombin time > 70%a | 1.3 [0.5–3.5] | 0.6 | ||
aPTT, patient/normal-value ratio < 1.5 | 1.2 [0.6–2.4] | 0.2 | ||