Comparison of the accuracy of neutrophil CD64, procalcitonin, and C-reactive protein for sepsis identification: a systematic review and meta-analysis

Annals of Intensive Care

Table 1 Main characteristics of the studies selected for the meta-analysis

References	Country	Study design	Mean age (years) total or case/control	Patient source	Sepsis/control (n)	Total (n)	Proportion of patients with sepsis (%)	Assay method	Cutoff	Sensitivity, specificity	TP (n)	FP (n)	FN (n)	TN (n)
Davis et al. [18]	USA	Prosp	–	EDs	38/62	100	38.0	In-house	2000 MESF	0.88, 0.71	33	18	5	44
Livaditi et al. [19]	Greece	Prosp	–	ICUs	47/12	59	79.7	In-house	2566 mol/cell	0.95, 1.00	44	0	3	12
Cardelli et al. [20]	Italy	Retro	63	ICUs	52/60	112	46.4	In-house	2398 mol/cell	0.96, 0.95	50	3	2	57
Hsu et al. [21]	China	Prosp	67/80	ICUs	55/11	66	83.3	In-house	4300 mol/cell	0.89, 0.96	49	1	6	10
Gamez-Diaz et al. [22]	Colombia	Prosp	–	EDs	404/206	610	66.2	Leuko64 kit	1.7 MESF	0.66, 0.65	266	73	138	133
Gibot et al. [23]	France	Prosp	61/60	ICUs	154/146	300	51.3	In-house	1.62	0.84, 0.95	130	7	24	139
Gros et al. [24]	France	Prosp	61/58	ICUs	148/145	293	50.5	Leuko64 kit	2.2	0.63, 0.89	93	16	55	129
Gerrits et al. [25]	Netherlands	Not described	74/69	ICUs	25/19	44	56.8	Leuko64 kit	1.66	1.00, 0.95	25	1	0	18
Dimoula et al. [26]	Belgium	Prosp	61/58	ICUs	103/365	468	22.0	In-house	230 MFI	0.89, 0.87	92	47	11	318
Righi et al. [27]	Italy	Prosp	59/58	ICUs	61/32	93	65.6	In-house	2000 ABC	0.90, 0.97	55	1	6	31
Godnic et al. [28]	Germany	Retro	–	ICUs	40/7	47	85.1	Leuko64 kit	1.95	0.76, 0.75	30	1	10	6
Bauer et al. [29]	USA	Prosp	66/59	ICUs	110/86	196	54.8	In-house	1040.5 mol/cell	0.76, 0.77	84	20	26	66
Muzlovic et al. [30]	Slovenia	–	–	ICUs	25/7	32	78.1	Leuko64 kit	1.58	1.00, 0.86	25	1	0	6
Tan et al. [31]	Malaysia	Prosp	–	EDs	42/9	51	82.4	In-house	45 ABC	0.81, 0.89	34	1	8	8

− not available, ABC antibody-binding capacity, EDs emergency departments, FCM flow cytometry, FN false negative, FP false positive, ICUs intensive care units, MFI median fluorescence intensity, Prosp prospective, Retro retrospective, TN true negative, TP true positive