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Table 1 Main characteristics of the studies selected for the meta-analysis

From: Comparison of the accuracy of neutrophil CD64, procalcitonin, and C-reactive protein for sepsis identification: a systematic review and meta-analysis

References Country Study design Mean age (years)
total or case/control
Patient source Sepsis/control (n) Total (n) Proportion of patients with sepsis (%) Assay method Cutoff Sensitivity, specificity TP (n) FP (n) FN (n) TN (n)
Davis et al. [18] USA Prosp EDs 38/62 100 38.0 In-house 2000 MESF 0.88, 0.71 33 18 5 44
Livaditi et al. [19] Greece Prosp ICUs 47/12 59 79.7 In-house 2566 mol/cell 0.95, 1.00 44 0 3 12
Cardelli et al. [20] Italy Retro 63 ICUs 52/60 112 46.4 In-house 2398 mol/cell 0.96, 0.95 50 3 2 57
Hsu et al. [21] China Prosp 67/80 ICUs 55/11 66 83.3 In-house 4300 mol/cell 0.89, 0.96 49 1 6 10
Gamez-Diaz et al. [22] Colombia Prosp EDs 404/206 610 66.2 Leuko64 kit 1.7 MESF 0.66, 0.65 266 73 138 133
Gibot et al. [23] France Prosp 61/60 ICUs 154/146 300 51.3 In-house 1.62 0.84, 0.95 130 7 24 139
Gros et al. [24] France Prosp 61/58 ICUs 148/145 293 50.5 Leuko64 kit 2.2 0.63, 0.89 93 16 55 129
Gerrits et al. [25] Netherlands Not described 74/69 ICUs 25/19 44 56.8 Leuko64 kit 1.66 1.00, 0.95 25 1 0 18
Dimoula et al. [26] Belgium Prosp 61/58 ICUs 103/365 468 22.0 In-house 230 MFI 0.89, 0.87 92 47 11 318
Righi et al. [27] Italy Prosp 59/58 ICUs 61/32 93 65.6 In-house 2000 ABC 0.90, 0.97 55 1 6 31
Godnic et al. [28] Germany Retro ICUs 40/7 47 85.1 Leuko64 kit 1.95 0.76, 0.75 30 1 10 6
Bauer et al. [29] USA Prosp 66/59 ICUs 110/86 196 54.8 In-house 1040.5 mol/cell 0.76, 0.77 84 20 26 66
Muzlovic et al. [30] Slovenia ICUs 25/7 32 78.1 Leuko64 kit 1.58 1.00, 0.86 25 1 0 6
Tan et al. [31] Malaysia Prosp EDs 42/9 51 82.4 In-house 45 ABC 0.81, 0.89 34 1 8 8
  1. − not available, ABC antibody-binding capacity, EDs emergency departments, FCM flow cytometry, FN false negative, FP false positive, ICUs intensive care units, MFI median fluorescence intensity, Prosp prospective, Retro retrospective, TN true negative, TP true positive