Table 3 Subgroup analysis of the diagnostic accuracy of CD64 for sepsis based on univariable metaregression analysis
Subgroup | Number of studies | Pooled sensitivity (95% CI) | P value | Pooled specificity (95% CI) | P value |
|---|---|---|---|---|---|
Source of patients | |||||
ICUs | 11 | 0.89 (0.83–0.94) | 0.80 | 0.91 (0.87–0.95) | 0.98 |
EDs | 3 | 0.79 (0.63–0.95) | 0.71 (0.58–0.84) | ||
Assay | |||||
In-house FCM | 9 | 0.88 (0.83–0.94) | 0.30 | 0.90 (0.84–0.96) | 0.27 |
Leuko64 kit | 5 | 0.82 (0.70–0.94) | 0.87 (0.77–0.98) | ||
Sample size | |||||
Number of patients ≧ 100 | 7 | 0.82 (0.73–0.90) | < 0.01* | 0.85 (0.77–0.92) | < 0.01* |
Number of patients < 100 | 7 | 0.91 (0.85–0.97) | 0.94 (0.89–1.00) | ||
Proportion of patients with sepsis | |||||
> 50% | 11 | 0.85 (0.78–0.91) | 0.01* | 0.91 (0.86–0.97) | 0.87 |
< 50% | 3 | 0.91 (0.86–0.95) | 0.85 (0.72–0.98) | ||
Continent | |||||
Asia | 2 | 0.86 (0.71–1.00) | 0.40 | 0.91 (0.76–1.00) | 0.81 |
Not Asia | 12 | 0.87 (0.81–0.93) | 0.89 (0.83–0.94) | ||