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Table 3 Subgroup analysis of the diagnostic accuracy of CD64 for sepsis based on univariable metaregression analysis

From: Comparison of the accuracy of neutrophil CD64, procalcitonin, and C-reactive protein for sepsis identification: a systematic review and meta-analysis

Subgroup Number of studies Pooled sensitivity (95% CI) P value Pooled specificity (95% CI) P value
Source of patients
 ICUs 11 0.89 (0.83–0.94) 0.80 0.91 (0.87–0.95) 0.98
 EDs 3 0.79 (0.63–0.95)   0.71 (0.58–0.84)  
Assay
 In-house FCM 9 0.88 (0.83–0.94) 0.30 0.90 (0.84–0.96) 0.27
 Leuko64 kit 5 0.82 (0.70–0.94)   0.87 (0.77–0.98)  
Sample size
Number of patients  100 7 0.82 (0.73–0.90) < 0.01* 0.85 (0.77–0.92) < 0.01*
 Number of patients < 100 7 0.91 (0.85–0.97)   0.94 (0.89–1.00)  
Proportion of patients with sepsis
 > 50% 11 0.85 (0.78–0.91) 0.01* 0.91 (0.86–0.97) 0.87
 < 50% 3 0.91 (0.86–0.95)   0.85 (0.72–0.98)  
Continent
 Asia 2 0.86 (0.71–1.00) 0.40 0.91 (0.76–1.00) 0.81
 Not Asia 12 0.87 (0.81–0.93)   0.89 (0.83–0.94)  
  1. EDs emergency departments, FCM flow cytometry, ICUs intensive care units
  2. *P < 0.05