Fig. 3
From: Severe toxicity from checkpoint protein inhibitors: What intensive care physicians need to know?
References: [3,4,5, 13, 16,17,18, 24, 33, 34, 40, 60, 71, 75, 88,89,90,91,92,93,94,95]
Frequencies of grade III and IV IrAEIrAE in studies. Meta-analysis of randomized control trials including CTLA4i (upper plot), CTLA4i + PD1i/PDL1i (middle plot) or PD1i/PDL1i (lower plot). The forest plots represent the frequencies of IrAEIrAE organ by organ. a Severe gastrointestinal irEA; b severe lung IrAE.