Risk factors for mortality in elderly and very elderly critically ill patients with sepsis: a prospective, observational, multicenter cohort study

Annals of Intensive Care

Table 2 Risk factors for hospital mortality between elderly and very elderly patients

	Elderly N = 566	p	Very elderly N = 161	p
Age (years) mean (SD)	72.4 (4.1)	0.412Ç	83.0 (2.8)	0.329 Ç
APACHE II modified score mean (SD)	19.3 (7.2)	< 0.001Ç	18.4 (7.4)	0.012 Ç
Number of organs mean (SD)	3.2 (1.5)	< 0.001*	3.0 (1.5)	0.547*
Sex (male) n (%)	356 (49.5)	0.078*	86 (54.8)	0.835*
Admission category n (%)
Medical	337 (47.1)	0.594*	66 (47.8)	0.056*
Urgent surgery	168 (46.5)		85 (58.2)
Elective surgery	48 (49.5)		8 (80.0)
Trauma	9 (64.3)		2 (100.0)
Source of infection n (%)
Pneumonia	223 (57.0)	< 0.001*	42 (61.8)	0.249*
Peritonitis	183 (45.7)		77 (57.0)
UTI	36 (26.3)		14 (36.8)
SSTI	19 (33.9)		4 (40.0)
Catheter-related bacteraemia	12 (40.0)		1 (50.0)
Other	72 (49.0)		21 (53.8)
Patient location at sepsis diagnosis n (%)
ED	188 (40.1)	< 0.001*	58 (45.7)	0.038*
Ward	271 (49.5)		87 (60.4)
ICU	107 (60.5)		16 (61.5)
Baseline acute organ dysfunction n (%)
Cardiovascular	494 (48.3)	0.151*	133 (54.3)	0.954*
Pulmonary	145 (58.0)	< 0.001*	38 (61.3)	0.208*
Renal	472 (50.2)	< 0.001*	132 (54.8)	0.686*
Hepatic	106 (55.5)	0.015*	25 (50.0)	0.512*
Thrombocytopenia	150 (57.0)	< 0.001*	31 (51.7)	0.658*
Coagulopathy	229 (55.2)	< 0.001*	64 (61.5)	0.063*
Sepsis resuscitation bundle N (%)$	42 (41.2)	0.185*	45 (28.6)	0.049*
Sepsis management bundle N (%)$	72 (43.6)	0.291*	75 (46.9)	0.378*

APACHE II acute physiology and chronic health evaluation II, ICU intensive care unit, LOS length of stay, UTI urinary tract infection, SSTI soft and skin tissue infections, ED emergency department
*χ2 tests; ^ÇStudent’s t tests, ^$sepsis resuscitation bundle (six tasks that should begin immediately and be accomplished within the first 6 h of presentation) and the sepsis management bundle (four tasks that should begin immediately and be completed within 24 h of presentation)