Risk factors for mortality in elderly and very elderly critically ill patients with sepsis: a prospective, observational, multicenter cohort study

Annals of Intensive Care

Table 3 Multivariate analysis for risk factors associated with hospital mortality between elderly and very elderly patients

	Elderly N = 566 aOR (CI 95%)	p	Very elderly N = 161 aOR (CI 95%)	p
Age (years)^a	1.1 (0.9–1.0)	0.683	1.1 (1.0–1.2)	0.04
Sex (male)	0.8 (0.6–1.1)	0.231	1.1 (0.7–1.7)	0.710
APACHE II modified scoreb	1.1 (1.1–1.1)	0.000	1.1 (1.1–1.2)	< 0.001
ICU LOS	0.9 (0.989–1.003)	0.235	1.031 (1.0–1.0)	0.009
Patient location at sepsis diagnosisc
Ward	1.5 (1.1–2.0)	0.002	1.5 (0.8–2.7)	0.130
ICU	2.6 (1.7–3.9)	0.000	0.6 (0.2–2.1)	0.507
ED (reference)	1.0		1.0
Source of infectiond
Peritonitis	0.6 (0.4–0.8)	0.005	0.9 (0.4–1.9)	0.856
UTI	0.3 (0.1–0.4)	0.000	0.3 (0.1–1.0)	0.059
SSTI	0.4 (0.2–0.8)	0.009	0.4 (0.1–2.1)	0.307
Catheter-related bacteremia	0.4 (0.2–1.0	0.055	0.9 (0.1–5.1)	0.243
Other	0.6 (0.4–1.4)	0.080	1.1 (0.4–2.7)	0.864
Pneumonia (reference)	1.0		1.0
Baseline acute organ dysfunction
Cardiovascular	1.0 (0.7–1.4)	0.886	0.6 (0.3–1.4)	0.316
Pulmonary	1.3 (0.9–1.8)	0.076	1.1 (0.5–2.3)	0.621
Renal	1.4 (1.0–2.0)	0.018	0.8 (0.4–1.7)	0.648
Hepatic	1.1 (0.8–1.7)	0.337	0.7 (0.3–1.6)	0.466
Thrombocytopenia	1.5 (1.1–2.1)	0.009	0.9 (0.4–2.1)	0.955
Coagulopathy	1.2 (0.9–1.7)	0.077	1.492 (0.8–2.6)	0.171
Sepsis resuscitation bundle N (%)^$	0.8 (0.5–1.3)	0.437	0.214 (0.1–0.9)	0.031
Sepsis management bundle N (%)^$	0.9 (0.6–1.3)	0.730	0.780 (0.3–1.8)	0.562

Elderly: 65–79 years of age and (2) very elderly ≥ 80 years of age
aOR adjusted odds ratio, APACHE II acute physiology and chronic health evaluation II, ICU intensive care unit; LOS length of stay, UTI urinary tract infection, SSTI soft and skin tissue infections
^aPer age
^bPer point
^cCompared with the ED department
^dCompared with pneumonia
^$Sepsis resuscitation bundle (six tasks that should begin immediately and be accomplished within the first 6 h of presentation) and the sepsis management bundle (four tasks that should begin immediately and be completed within 24 h of presentation)