Skip to main content

Table 3 Viscoelastic and aggregometric POCT

From: Acute fibrinolysis shutdown occurs early in septic shock and is associated with increased morbidity and mortality: results of an observational pilot study

Timepoints Baseline Pre Onset 3 h 6 h 12 h 24 h 48 h 7d
Groups Healthy Surgical Surgical Sepsis Surgical Sepsis Surgical Sepsis Surgical Sepsis Surgical Sepsis Surgical Sepsis Surgical Sepsis
Viscoelastic POCT (EXTEM test)
CT (s) (normal range 38–79 s) 57.0 (54.0–60.0) 60.0 (55.5–67.0) 60.0 (55.0–70.0) 81.5 (67.8–91.8) 60.0 (54.5–65.5) 78.0 (70.8–89.8) 59.0 (53.0–66.0) 82.0 (67.0–88.0) 66.5 (61.3–71.0) 82.0 (74.0–90.0) 59.0 (55.0–64.0) 81.0 (69.0–86.0) 62.0 (57.0–69.0) 72.0 (66.8–78.0) 71.0 (64.0–78.0) 76.0 (66.0–82.5)
  < 0.001*** < 0.001*** < 0.001*** < 0.001*** < 0.001*** 0.001** 0.358
LI 45 min (%) (normal range > 85%) 96.0 (94.0–98.0) 97.0 (96.0–98.5) 98.0 (96.0–98.5) 99.0 (98.0–100.0) 97.0 (96.0–99.0) 99.0 (98.0–100.0) 97.0 (96.0–99.0) 99.0 (98.0–100.0) 96.0 (95.0–98.0) 99.0 (98.0–100.0) 95.0 (92.0–97.0) 100.0 (98.0–100.0) 95.0 (93.0–97.0) 100.0 (98.0–100.0) 97.0 (94.5–98.0) 99.0 (98.5–100.0)
  0.032* 0.004** 0.008** < 0.001*** < 0.001*** < 0.001*** 0.002**
LI 60 min (%) (normal range > 85%) 92.0 (90.0–93.75) 93.0 (92.0–95.0) 96.0 (94.5–96.0) 97.0 (96.0–99.0) 95.0 (93.0–97.0) 97.0 (95.3–99.0) 94.0 (92.0–96.0) 98.0 (96.0–99.0) 93.0 (91.0–94.0) 97.0 (95.0–99.0) 88.0 (86.0–92.0) 98.0 (95.0–99.0) 90.5 (87.0–93.75) 98.5 (96.0– 100.0) 92.0 (90.0–95.0) 97.5 (96.3–98.8)
  0.027* 0.032* 0.079 < 0.001*** < 0.001*** < 0.001*** 0.005**
Aggregometric POCT
ADP test AUC (U*min) (normal range 53–122) 65.0 (52.8–82.8) 63.5 (42.3–83.8) 83.5 (47.0–100.5) 29.0 (19.8–58.8) 58.0 (25.5–92.0) 36.0 (19.0–55.5) 52.0 (37.0–108.0) 34.5 (15.8–60.8) 73.0 (37.0–197.5) 48.0 (18.0–70.0) 58.5 (39.8–80.5) 40.0 (17.0–61.0) 53.0 (34.5–69.5) 27.0 (13.3–44.8) 104.0 (80.0–139.5) 71.0 (31.0–108.0)
  < 0.001*** 0.143 0.009** 0.101 0.022* 0.008** 0.059
ASPI test AUC (U*min) (normal range 75–136) 107.0 (94.8–117.8) 93.5 (77.3–112.8) 78.5 (45.5–104.3) 64.5 (24.3–92.0) 41.0 (28.5–88.5) 57.0 (22.0–105.0) 45.0 (27.0–89.0) 53.0 (27.8–100.8) 55.0 (27.0–75.5) 52.0 (24.0–107.0) 48.5 (19.8–74.3) 58.0(26.0–104.0) 37.5(23.5–58.0) 49.0 (23.8–111.8) 118.0 (66.5–146.5) 102.0 (75.5–143.5)
  0.451 0.564 0.583 0.444 0.91 0.191 0.729
COL test AUC (U*min) (normal range 46–117) 87.0 (72.0–106.8) 63.5 (49.3–80.3) 63.0 (42.0–98.0) 43.0 (33.3–66.5) 53.0 (32.0–100.0) 58.0 (26.5–116.0) 86.0 (49.0–116.0) 55.5 (22.3–87.0) 94.0 (37.5–119.0) 77.0 (29.0–95.0) 58.5 (29.8–92.0) 56.0 (35.0–88.0) 52.0 (26.5–69.5) 54.0 (29.3–96.0) 91.0 (64.0–110.0) 59.0 (42.5–120.5)
  0.680 0.932 0.062 0.277 1.00 0.406 0.405
ADP test AUC (U*min) (normal range 53–122) 65.0 (52.8–82.8) 63.5 (42.3–83.8) 83.5 (47.0–100.5) 29.0 (19.8–58.8) 58.0 (25.5–92.0) 36.0 (19.0–55.5) 52.0 (37.0–108.0) 34.5 (15.8–60.8) 73.0 (37.0–197.5) 48.0 (18.0–70.0) 58.5 (39.8–80.5) 40.0 (17.0–61.0) 53.0 (34.5–69.5) 27.0 (13.3–44.8) 104.0 (80.0–139.5) 71.0 (31.0–108.0)
  < 0.001*** 0.143 0.009** 0.101 0.022* 0.008** 0.059
  1. Data are presented by median and interquartile range (Q1–Q3)
  2. CT clotting time, LI lysis index, AUC area under the curve
  3. A P value < 0.05 was considered statistically significant. Concerning symbolism and higher orders of significance: *P < 0.05, **P < 0.01, ***P < 0.001