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Annals of Intensive Care

Table 3 Viscoelastic and aggregometric POCT

From: Acute fibrinolysis shutdown occurs early in septic shock and is associated with increased morbidity and mortality: results of an observational pilot study

Timepoints

Baseline

Pre

Onset

3 h

6 h

12 h

24 h

48 h

7d

Groups

Healthy

Surgical

Surgical

Sepsis

Surgical

Sepsis

Surgical

Sepsis

Surgical

Sepsis

Surgical

Sepsis

Surgical

Sepsis

Surgical

Sepsis

Viscoelastic POCT (EXTEM test)

CT (s) (normal range 38–79 s)

57.0 (54.0–60.0)

60.0 (55.5–67.0)

60.0 (55.0–70.0)

81.5 (67.8–91.8)

60.0 (54.5–65.5)

78.0 (70.8–89.8)

59.0 (53.0–66.0)

82.0 (67.0–88.0)

66.5 (61.3–71.0)

82.0 (74.0–90.0)

59.0 (55.0–64.0)

81.0 (69.0–86.0)

62.0 (57.0–69.0)

72.0 (66.8–78.0)

71.0 (64.0–78.0)

76.0 (66.0–82.5)

 

< 0.001***

< 0.001***

< 0.001***

< 0.001***

< 0.001***

0.001**

0.358

LI 45 min (%) (normal range > 85%)

96.0 (94.0–98.0)

97.0 (96.0–98.5)

98.0 (96.0–98.5)

99.0 (98.0–100.0)

97.0 (96.0–99.0)

99.0 (98.0–100.0)

97.0 (96.0–99.0)

99.0 (98.0–100.0)

96.0 (95.0–98.0)

99.0 (98.0–100.0)

95.0 (92.0–97.0)

100.0 (98.0–100.0)

95.0 (93.0–97.0)

100.0 (98.0–100.0)

97.0 (94.5–98.0)

99.0 (98.5–100.0)

 

0.032*

0.004**

0.008**

< 0.001***

< 0.001***

< 0.001***

0.002**

LI 60 min (%) (normal range > 85%)

92.0 (90.0–93.75)

93.0 (92.0–95.0)

96.0 (94.5–96.0)

97.0 (96.0–99.0)

95.0 (93.0–97.0)

97.0 (95.3–99.0)

94.0 (92.0–96.0)

98.0 (96.0–99.0)

93.0 (91.0–94.0)

97.0 (95.0–99.0)

88.0 (86.0–92.0)

98.0 (95.0–99.0)

90.5 (87.0–93.75)

98.5 (96.0– 100.0)

92.0 (90.0–95.0)

97.5 (96.3–98.8)

 

0.027*

0.032*

0.079

< 0.001***

< 0.001***

< 0.001***

0.005**

Aggregometric POCT

ADP test AUC (U*min) (normal range 53–122)

65.0 (52.8–82.8)

63.5 (42.3–83.8)

83.5 (47.0–100.5)

29.0 (19.8–58.8)

58.0 (25.5–92.0)

36.0 (19.0–55.5)

52.0 (37.0–108.0)

34.5 (15.8–60.8)

73.0 (37.0–197.5)

48.0 (18.0–70.0)

58.5 (39.8–80.5)

40.0 (17.0–61.0)

53.0 (34.5–69.5)

27.0 (13.3–44.8)

104.0 (80.0–139.5)

71.0 (31.0–108.0)

 

< 0.001***

0.143

0.009**

0.101

0.022*

0.008**

0.059

ASPI test AUC (U*min) (normal range 75–136)

107.0 (94.8–117.8)

93.5 (77.3–112.8)

78.5 (45.5–104.3)

64.5 (24.3–92.0)

41.0 (28.5–88.5)

57.0 (22.0–105.0)

45.0 (27.0–89.0)

53.0 (27.8–100.8)

55.0 (27.0–75.5)

52.0 (24.0–107.0)

48.5 (19.8–74.3)

58.0(26.0–104.0)

37.5(23.5–58.0)

49.0 (23.8–111.8)

118.0 (66.5–146.5)

102.0 (75.5–143.5)

 

0.451

0.564

0.583

0.444

0.91

0.191

0.729

COL test AUC (U*min) (normal range 46–117)

87.0 (72.0–106.8)

63.5 (49.3–80.3)

63.0 (42.0–98.0)

43.0 (33.3–66.5)

53.0 (32.0–100.0)

58.0 (26.5–116.0)

86.0 (49.0–116.0)

55.5 (22.3–87.0)

94.0 (37.5–119.0)

77.0 (29.0–95.0)

58.5 (29.8–92.0)

56.0 (35.0–88.0)

52.0 (26.5–69.5)

54.0 (29.3–96.0)

91.0 (64.0–110.0)

59.0 (42.5–120.5)

 

0.680

0.932

0.062

0.277

1.00

0.406

0.405

ADP test AUC (U*min) (normal range 53–122)

65.0 (52.8–82.8)

63.5 (42.3–83.8)

83.5 (47.0–100.5)

29.0 (19.8–58.8)

58.0 (25.5–92.0)

36.0 (19.0–55.5)

52.0 (37.0–108.0)

34.5 (15.8–60.8)

73.0 (37.0–197.5)

48.0 (18.0–70.0)

58.5 (39.8–80.5)

40.0 (17.0–61.0)

53.0 (34.5–69.5)

27.0 (13.3–44.8)

104.0 (80.0–139.5)

71.0 (31.0–108.0)

 

< 0.001***

0.143

0.009**

0.101

0.022*

0.008**

0.059

  1. Data are presented by median and interquartile range (Q1–Q3)
  2. CT clotting time, LI lysis index, AUC area under the curve
  3. A P value < 0.05 was considered statistically significant. Concerning symbolism and higher orders of significance: *P < 0.05, **P < 0.01, ***P < 0.001
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