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Annals of Intensive Care
Fig. 3 | Annals of Intensive Care

Fig. 3

From: The clinical efficacy of intravenous IgM-enriched immunoglobulin (pentaglobin) in sepsis or septic shock: a meta-analysis with trial sequential analysis

Fig. 3

Trial sequential analysis for mortality in trials: a relative risk of 0.60, two-sided boundary, incidence of 25% in IVIgGM group, incidence of 42.7% in control group, a low bias estimated relative risk reduction of 80%, α of 5%, power of 80% were set. The required information size was calculated as 1019. Z-curve has across-trial sequential monitoring boundary for benefit

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