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Annals of Intensive Care

Table 3 Summary of findings table

From: The clinical efficacy of intravenous IgM-enriched immunoglobulin (pentaglobin) in sepsis or septic shock: a meta-analysis with trial sequential analysis

Patient or population: patients with Sepsis or septic shock

Settings: Intensive care medicine

Intervention: IVIgGM

Comparison: Control

Outcomes

Illustrative comparative risks* (95% CI)

Relative effect(95% CI)

No of Participants(studies)

Quality of the evidence(GRADE)

Assumed risk

Corresponding risk

 

Control

IVIgGM

   

New OutcomeFollow-up: 12-70 days

Study population

RR 0.60 (0.52 to 0.69)

1530

(19 studies)

⊕⊕⊝⊝

low 1

429 per 1000

258 per 1000 (223 to 296)

Moderate

412 per 1000

247 per 1000 (214 to 284)

Length of mechanical ventilation

The mean length of mechanical ventilation in the intervention groups was 3.16 lower (5.71 lower to 0.61 lower)

 

264

(4 studies)

⊕⊕⊝⊝

low 1

Length of stay on ICU

The mean length of stay on ICU in the intervention groups was 0.38 higher (3.55 lower to 2.80 higher)

 

530

(8 studies)

⊕⊝⊝⊝

very low 1

  1. *The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI)
  2. CI confidence interval, RR risk ratio, ICU intensive care medicine
  3. GRADE Working Group grades of evidence
  4. High quality: Further research is very unlikely to change our confidence in the estimate of effect
  5. Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate
  6. Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate
  7. Very low quality: We are very uncertain about the estimate
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