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Table 1 Demographic, clinical and laboratory characteristics of cirrhotic patients with (Aspergillus +) or without (Aspergillus −) positive culture of Aspergillus spp

From: Invasive pulmonary aspergillosis in cirrhotic patients: analysis of a 10-year clinical experience

Variables

Aspergillus +

n = 60

Aspergillus –

n = 148

p value

Age (years), mean (SD)

55.4 (12.6)

54.7 (11.5)

0.6

Gender (male), n (%)

51 (85)

125 (84)

0.38

Aetiology of cirrhosis, n (%)

  

< 0.001

 Alcohol

25 (42)

106 (71)

 

 Viral

23 (38)

32 (22)

 

 Other

12 (20)

10 (7)

 

Comorbidities, n (%)

 COPD

23 (38)

20 (14)

0.001

 Immunosuppressive treatment

15 (25)

22 (15)

0.08

 Ascites

24 (40)

47 (32)

0.82

Life support n (%)

 Mechanical ventilation

31 (52)

77 (52)

> 0.99

 Catecholamine

30 (50)

50 (34)

0.03

 Renal replacement therapy

13 (22)

13 (9)

0.01

 Liver support

7 (12)

5 (3.4)

0.02

Laboratory data, mean (SD)

 INR

2.01 (1.64)

2.4 (2)

0.23

 Serum bilirubin (µmol/l)

131 (159)

151(165)

0.056

 Serum creatinine (µmol/l)

155 (151)

149 (131)

0.98

 Serum sodium (mmol/l)

135 (5.3)

134 (7.7)

0.89

Prognostic score, mean (SD)

 Child–Pugh score

11.2 (2.8)

10.6 (2.3)

0.15

 MELD score

21 (11.2)

22,6 (9.8)

0.25

 SAPS II score

46 (20)

44 (19,7)

0.68

 SOFA score

9.8 (7.3)

8.6 (4.9)

0.55

ACLF grade n (%)

  

0.26

 ACLF grade 0

17 (28)

60 (41)

 

 ACLF grade 1

11 (18)

30 (20)

 

 ACLF grade 2

9 (15)

19 (13)

 

 ACLF grade 3

23 (38)

39 (26)

 

Outcome, n (%)

 Hospital mortality

20 (33)

52 (35)

0.8

 Liver transplantation

5 (8)

13 (9)

0.91

  1. Significant parameters (p value < 0.05)
  2. IPA invasive pulmonary aspergillosis, COPD Chronic Obstructive Pulmonary Disease, MELD Model of End-Stage Liver Disease, ACLF Acute-On-Chronic Liver Failure, ICU Intensive Care Unit, SAPS II Simplified Acute Physiology Score