Skip to main content

Table 2 Demographic, clinical and laboratory characteristics of patients with positive culture of Aspergillus spp., invasive pulmonary aspergillosis and Aspergillus spp. colonisation

From: Invasive pulmonary aspergillosis in cirrhotic patients: analysis of a 10-year clinical experience

Variables

Whole population

n = 60

IPA

n = 17

Aspergillus spp. colonisation

n = 43

p value

Age (years), mean (SD)

55.4 (12.6)

56 (14.5)

55.2 (11.8)

0.64

Gender (male), n (%)

51 (85)

15 (88)

36 (84)

0.65

Aetiology of cirrhosis, n (%)

   

0.60

 Alcohol

25 (42)

8 (47)

17 (40)

 

 Viral

23 (38)

7 (41)

16 (37)

 

 Other

12 (20)

2 (12)

10 (23)

 

Severe alcoholic hepatitis, n (%)

11 (18)

6 (35)

5 (12)

0.06

Comorbidities, n (%)

 Diabetes

14 (23)

2 (12)

12 (28)

0.18

 COPD

23 (38)

11 (65)

12 (28)

0.008

 Smoking history

23 (38)

6 (35)

17 (40)

0.76

 Heart disease

3 (5)

0 (0)

3 (7)

0.26

 Immunosuppressive treatment

15 (25)

7 (41)

8 (19)

0.09

 Ascites

24 (40)

9 (53)

15 (35)

0.19

 Encephalopathy

17 (28)

9 (53)

8 (19)

0.007

Life support n (%)

 Mechanical ventilation

31 (52)

12 (71)

19 (44)

0.06

 Catecholamine

30 (50)

12 (71)

18 (42)

0.04

 Renal replacement therapy

13 (22)

7 (41)

6 (14)

0.02

 Liver support

7 (12)

4 (24)

3 (7)

0.07

Laboratory data, mean (SD)

 INR

2.01 (1.64)

2.2 (1.5)

1.9 (1.7)

0.56

 Serum bilirubin (µmol/l)

131 (159)

172 (169)

115 (154)

0.16

 Serum creatinine (µmol/l)

155 (151)

180 (151)

145 (152)

0.14

 Serum sodium (mmol/l)

135 (5.3)

134 (5.8)

135 (5.3)

0.61

 Albumin (g/L)

31 (8)

34 .4 (8.6)

30.9 (7.9)

0.20

 Leucocytes (/mm3)

10.9 (8.4)

13.8 (12.4)

9.9 (6.3)

0.69

 Platelets (/mm3)

123 (81)

109 (69)

127 (85)

0.66

Prognostic score, mean (SD)

 Child–Pugh score

11.2 (2.8)

11.8 (3.1)

10.8 (2.6)

0.17

 SAPS II

46 (20)

48 (25)

45 (18)

0.32

 MELD score

21 (11.2)

23.2 (13.3)

20.1 (10.4)

0.44

 SOFA score

9.8 (7.3)

13.4 (8.5)

8.3 (6.4)

0.002

ACLF grade n (%)

   

0.17

 ACLF grade 0

17 (28)

4 (24)

13 (30)

 

 ACLF grade 1

11 (18)

1 (6)

10 (23)

 

 ACLF grade 2

9 (15)

2 (12)

7 (16)

 

 ACLF grade 3

23 (38)

10 (59)

13 (30)

 

Outcome, n (%)

 Hospital mortality

20 (33)

12 (71)

8 (19)

< 0.001

 One-year mortality

41 (68)

14 (82)

27 (63)

0.14

 Liver transplantation

5 (8)

1 (6)

4 (9)

0.66

  1. Significant parameters (p value < 0.05)
  2. IPA invasive pulmonary aspergillosis, COPD chronic obstructive pulmonary disease, MELD Model of End-Stage Liver Disease, ACLF Acute-On-Chronic Liver Failure, ICU intensive care unit, SAPS II Simplified Acute Physiology Score