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Annals of Intensive Care
Fig. 3 | Annals of Intensive Care

Fig. 3

From: Effects of chloride content of intravenous crystalloid solutions in critically ill adult patients: a meta-analysis with trial sequential analysis of randomized trials

Fig. 3

Trial sequential analysis for in-hospital mortality. TSA was performed based on a relative risk reduction of in-hospital mortality of 6.42% according to 10.2% in balanced crystalloids group and 10.9% in 0.9% saline group in eight trials with 19,301 patients reporting in-hospital mortality. A required diversity-adjusted information size of 80,946 patients was calculated. The cumulated Z-curve (blue) failed to reach the traditional boundary (p = 0.05), the trial sequential monitoring boundary as well as the estimated information size boundary. TSA is for trial sequential analysis

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