Fig. 7

Trial sequential analysis for in-hospital mortality in subgroup of non-traumatic brain injury patients. Trial sequential analysis for a relative risk reduction of 10.48% according to the in-hospital mortality of 9.4% and 10.5% of patients without TBI in balanced crystalloids group and 0.9% saline group, respectively [9, 10, 20,21,22], was performed. A required diversity-adjusted information size of 31,123 patients was calculated. The cumulated Z-curve (blue) crossed the conventional line, but reached neither the trial sequential monitoring boundary for benefit nor the estimated information size boundary. TBI is for traumatic brain injury