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Table 1 Characteristics of the included studies

From: Effects of chloride content of intravenous crystalloid solutions in critically ill adult patients: a meta-analysis with trial sequential analysis of randomized trials

References No. of patients (analyzed/included) Setting Balanced crystalloid fluid type Follow-up period Volume of fluid in liters, mean ± SD, median (IQR) Outcomes
Report on mortality Report on new RRT use Report on development of stage 2 or higher stage AKI
Waters et al. [20] 66/66 Perioperative transferred to ICU: abdominal aortic aneurysm repair Lactated Ringers (LR) In-hospital Balanced: 6.9 (5.7–7.9)
0.9% saline: 7.0 (5.0–8.5)
×
Takil et al. [21] 30/30 Perioperative transferred to ICU: major spine surgery LR In-hospital Balanced: 5.1 ± 0.9
0.9% saline: 5.1 ± 1.5
×
Van Zyl et al. [22] 54/57 Critically ill patients: diabetic ketoacidosis LR In-hospital NR × ×
Young et al. [23] 46/65 Critically ill patients: trauma Plasma-Lyte In-hospital at day 30 Balanced:10.3 ± 6.5
0.9% saline: 9.0 ± 5.5
×
Young et al. [9] 2262/2262 Critically ill patients: mixed Plasma-Lyte In-hospital Balanced: 2.0 (1.0–3.5)
0.9% saline: 2.0 (1.0–3.2)
Verma et al. [24] 67/70 Critically ill patients: mixed Plasma-Lyte In-hospital Balanced: 2.9
0.9% saline: 3.4
Semler et al. [25] 974/974 Critically ill patients: mixed LR or Plasma-Lyte 60 days Balanced: 1.6 (0.5–3.6)
0.9% saline: 1.4 (0.5–3.4)
Semler et al. [10] 15,802/15,802 Critically ill patients: mixed LR or Plasma-Lyte 60 days Balanced: 1.0 (0–3.0)
0.9% saline: 1.0 (0–3.0)
  1. No. number, SD standard difference, IQR interquartile range, RRT renal replacement therapy, AKI acute kidney injury according to KDIGO criterion, LR lactated Ringers, NR no report