Table 1 Characteristics of the included studies
| References | No. of patients (analyzed/included) | Setting | Balanced crystalloid fluid type | Follow-up period | Volume of fluid in liters, mean ± SD, median (IQR) | Outcomes | ||
|---|---|---|---|---|---|---|---|---|
| Report on mortality | Report on new RRT use | Report on development of stage 2 or higher stage AKI | ||||||
| Waters et al. [20] | 66/66 | Perioperative transferred to ICU: abdominal aortic aneurysm repair | Lactated Ringers (LR) | In-hospital |
Balanced: 6.9 (5.7–7.9) 0.9% saline: 7.0 (5.0–8.5) | √ | × | √ |
| Takil et al. [21] | 30/30 | Perioperative transferred to ICU: major spine surgery | LR | In-hospital |
Balanced: 5.1 ± 0.9 0.9% saline: 5.1 ± 1.5 | √ | √ | × |
| Van Zyl et al. [22] | 54/57 | Critically ill patients: diabetic ketoacidosis | LR | In-hospital | NR | √ | × | × |
| Young et al. [23] | 46/65 | Critically ill patients: trauma | Plasma-Lyte | In-hospital at day 30 |
Balanced:10.3 ± 6.5 0.9% saline: 9.0 ± 5.5 | √ | × | √ |
| Young et al. [9] | 2262/2262 | Critically ill patients: mixed | Plasma-Lyte | In-hospital |
Balanced: 2.0 (1.0–3.5) 0.9% saline: 2.0 (1.0–3.2) | √ | √ | √ |
| Verma et al. [24] | 67/70 | Critically ill patients: mixed | Plasma-Lyte | In-hospital |
Balanced: 2.9 0.9% saline: 3.4 | √ | √ | √ |
| Semler et al. [25] | 974/974 | Critically ill patients: mixed | LR or Plasma-Lyte | 60 days |
Balanced: 1.6 (0.5–3.6) 0.9% saline: 1.4 (0.5–3.4) | √ | √ | √ |
| Semler et al. [10] | 15,802/15,802 | Critically ill patients: mixed | LR or Plasma-Lyte | 60 days |
Balanced: 1.0 (0–3.0) 0.9% saline: 1.0 (0–3.0) | √ | √ | √ |
