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Table 1 Mechanisms contributing to the development of hyperkalemia

From: Management of hyperkalemia in the acutely ill patient

Mechanisms contributing to the development of hyperkalemia

Increased extracellular K+

Decreased K+ elimination

Tissue injury

 Hemolysis

 Rhabdomyolysis

 Tumor lysis syndrome

K+ shift in extracellular space

 Mineral acidosis (i.e., hyperchoride acidosis)

 Succinylcholine

Inability to enter into myocyte

 Diabetes mellitus

 Hyperglycemia

 Hypertonicity

 β2-receptor antagonists

 Aldosterone blockers

 Cardiac glycosides

High acute iatrogenic K+ load

 Increased dietary intake

 Blood transfusion

 Error of injection

AKI

 Hypovolemia

 Sepsis

Acidosis treatment

 RAAS inhibitor

 Calcineurine inhibitor

 Cardiac glycosides

  1. K+ potassium, RAAS renin–angiotensin–aldosterone system