Chest CT scan and alveolar procollagen III to predict lung fibroproliferation in acute respiratory distress syndrome

Annals of Intensive Care

Table 2 CT scan fibrosis scores according to lung fibroproliferation (NT-PCP-III > 9µG/L)

	No lung fibroproliferation (n = 175) (NT-PCP-III ≤ 9 µG/L)	Lung fibroproliferation (n = 53) (NT-PCP-III > 9 µG/L)	p value
Crude fibrosis score	12 [9–17]	14 [11–21]	0.002
Ground glass	7 [5–12]	9 [6–14]	0.007
Honeycombing	4 [4–5]	5 [3–5]	0.015
Corrected fibrosis score	2.8 [2.2–4.0]	3.4 [2.5–4.7]	< 0.001
Ground glass	1.8 [1.2–3.0]	2.3 [1.5–3.3]	0.003
Honeycombing	1 [1–1]	1 [1–1]	< 0.001

Values are expressed as median [IQR]. NT-PCP-III: N-terminal peptide for type III procollagen. Each lobe of the lung was scored on a scale of 0–5 points for both ground glass and honeycombing abnormality. In the case of lobectomy or when consolidation was observed in more than 75% of a lobe, the score was not used for this lobe. The CT scan crude fibrosis score was calculated as the sum of points obtained for each lobe. We corrected the score by reporting it to the number of lobes evaluated (corrected fibrosis score = crude fibrosis score/number of lobes evaluated)
p values were calculated by linear mixed model