Chest CT scan and alveolar procollagen III to predict lung fibroproliferation in acute respiratory distress syndrome

Annals of Intensive Care

Table 3 Characteristics of ARDS, ventilatory parameters and outcome according to lung fibroproliferation and CT scan fibrosis score

	CT scan day			BAL day
	Corrected score < 3 (n = 105)	Corrected score ≥ 3 (n = 123)	p	NT-PCP-III ≤ 9 µG/L (n = 175)	NT-PCP-III > 9 µG/L (n = 53)	p
Minute ventilation (L/min)	10.2 [7.9–11.8]	10.3 [8.8–11.7]	0.66	9.6 [8.1–11.0]	9.9 [8.37–12.0]	0.89
Tidal volume (mL/kg PBW)	6.3 [5.5–7.3]	6.3 [4.9–7.3]	0.68	6.3 [5.7–6.9]	6.1 [5.3–6.8]	0.82
Respiratory rate (cycle/min)	24 [20–28]	25 [22–30]	0.39	24 [20–28]	25 [22–30]	0.34
Plateau pressure (cmH₂O)	23 [20–26]	26 [22–28]	0.08	25 [22–27]	26 [20–29]	0.91
Driving pressure (cmH₂O)	12 [10–15]	14 [12–17]	0.77	14 [11–16]	14 [12–18]	0.69
PEEP (cmH₂O)	10 [7–12]	10 [8–12]	0.76	10 [8–12]	10 [8–14]	0.24
Respiratory system compliance (mL/cmH₂O)	33 [24–40]	24 [18–34]	0.10	28 [22–37]	26 [19–35]	0.84
pH	7.39 [7.32–7.43]	7.38 [7.32–7.44]	0.90	7.39 [7.32–7.44]	7.37 [7.31–7.44]	0.89
PaO₂/FiO₂ (mmHg)	162 [111–224]	166 [119–213]	0.75	160 [120–221]	143 [111–187]	0.19
PaCO₂ (mmHg)	44 [37–50]	44 [35–50]	0.50	43 [36–40]	46 [40–56]	0.07
SOFA	7 [5–9]	7 [5–9]	0.25	7 [5–9]	7 [6–9]	0.57
Ventilator-free days at day 60 (days)	31 [0–52]	0 [0–38]	0.001	23 [0–43]	0 [0–45]	0.25
Length of ICU stay (days)	23 [12–41]	28 [15–43]	0.21	27 [14–38]	30 [14–55]	0.31
ICU mortality [n (%)]	29 (27.6)	54 (43.9)	0.02	55 (31.4)	28 (52.8)	0.01

Values are expressed as median [IQR]
ARDS acute respiratory distress syndrome, BAL bronchoalveolar lavage, PBW predicted body weight, PEEP positive end-expiratory pressure, SOFA sequential organ failure assessment, NT-PCP-III NT-peptide for type III procollagen
p values were calculated by linear mixed model, excepted for ICU mortality by generalized linear model (generalized equation estimation)