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Table 3 Characteristics of ARDS, ventilatory parameters and outcome according to lung fibroproliferation and CT scan fibrosis score

From: Chest CT scan and alveolar procollagen III to predict lung fibroproliferation in acute respiratory distress syndrome

  CT scan day BAL day
Corrected score < 3 (n = 105) Corrected score ≥ 3 (n = 123) p NT-PCP-III ≤ 9 µG/L (n = 175) NT-PCP-III > 9 µG/L (n = 53) p
Minute ventilation (L/min) 10.2 [7.9–11.8] 10.3 [8.8–11.7] 0.66 9.6 [8.1–11.0] 9.9 [8.37–12.0] 0.89
Tidal volume (mL/kg PBW) 6.3 [5.5–7.3] 6.3 [4.9–7.3] 0.68 6.3 [5.7–6.9] 6.1 [5.3–6.8] 0.82
Respiratory rate (cycle/min) 24 [20–28] 25 [22–30] 0.39 24 [20–28] 25 [22–30] 0.34
Plateau pressure (cmH2O) 23 [20–26] 26 [22–28] 0.08 25 [22–27] 26 [20–29] 0.91
Driving pressure (cmH2O) 12 [10–15] 14 [12–17] 0.77 14 [11–16] 14 [12–18] 0.69
PEEP (cmH2O) 10 [7–12] 10 [8–12] 0.76 10 [8–12] 10 [8–14] 0.24
Respiratory system compliance (mL/cmH2O) 33 [24–40] 24 [18–34] 0.10 28 [22–37] 26 [19–35] 0.84
pH 7.39 [7.32–7.43] 7.38 [7.32–7.44] 0.90 7.39 [7.32–7.44] 7.37 [7.31–7.44] 0.89
PaO2/FiO2 (mmHg) 162 [111–224] 166 [119–213] 0.75 160 [120–221] 143 [111–187] 0.19
PaCO2 (mmHg) 44 [37–50] 44 [35–50] 0.50 43 [36–40] 46 [40–56] 0.07
SOFA 7 [5–9] 7 [5–9] 0.25 7 [5–9] 7 [6–9] 0.57
Ventilator-free days at day 60 (days) 31 [0–52] 0 [0–38] 0.001 23 [0–43] 0 [0–45] 0.25
Length of ICU stay (days) 23 [12–41] 28 [15–43] 0.21 27 [14–38] 30 [14–55] 0.31
ICU mortality [n (%)] 29 (27.6) 54 (43.9) 0.02 55 (31.4) 28 (52.8) 0.01
  1. Values are expressed as median [IQR]
  2. ARDS acute respiratory distress syndrome, BAL bronchoalveolar lavage, PBW predicted body weight, PEEP positive end-expiratory pressure, SOFA sequential organ failure assessment, NT-PCP-III NT-peptide for type III procollagen
  3. p values were calculated by linear mixed model, excepted for ICU mortality by generalized linear model (generalized equation estimation)