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Table 1 Baseline characteristics of the patients

From: Effects of mean arterial pressure on arousal in sedated ventilated patients with septic shock: a SEPSISPAM post hoc exploratory study

Characteristics at baseline

Low-target group N = 253 (47.6%)

High-target group N = 279 (52.4%)

P

Age (years); mean ± SD

66 ± 14

65 ± 13

0.38

Simplified Acute Physiology Score II; mean ± SD

59.0 ± 15.4

57.2 ± 15.8

0.19

Sequential Organ Failure Assessment Score; mean ± SD

11.06 ± 3.1

11.0 ± 3.1

0.83

Male sex; n (%)

168 (66.4)

196 (70.3)

0.34

Preexisting medical conditions; n (%)

 Ischemic heart disease

31 (12.3)

28 (10)

0.426

 Chronic heart failure

36 (14.2)

42 (15.1)

0.79

 Chronic obstructive pulmonary disease

32 (12.6)

39 (14)

0.65

 Chronic renal failure

21 (8.3)

7 (2.5)

0.003

 Liver cirrhosis

13 (5.1)

18 (6.5)

0.52

 Diabetes

59 (23.3)

51/278 (18.3)

0.16

 Cancer or autoimmune disease

81 (32)

100 (35.8)

0.35

 Chronic arterial hypertension

112 (44.3)

120 (43)

0.77

Source of infection; n (%)

 Lung

142/249 (57)

156/275 (56.7)

0.95

 Abdomen

45/249 (18.1)

48/275 (17.5)

0.85

 Urinary tract

18/249 (7.2)

25/275 (9.1)

0.44

 Other

44/249 (17.7)

46/275 (16.7)

0.78

Hemodynamic and biochemical variables; mean ± SD

 Mean arterial pressure (mmHg)/n

74 ± 14

73 ± 14

0.38

 Arterial pH/n

7.27 ± 0.14

7.28 ± 0.12

0.45

 Serum lactate (mmol/L)/n

3.84 ± 3.85

3.31 ± 3.26

0.10

 Fluid therapy before inclusion (mL)

2993 ± 1405

3068 ± 1378

0.55

Acute kidney injury, n (%)a

86 (34)

77 (27.6)

0.11

  1. aAcute kidney injury was defined as plasma creatinine level > 1.9 mg/dL or urinary output, < 500 ml per day