Characteristics at baseline | Low-target group N = 253 (47.6%) | High-target group N = 279 (52.4%) | P |
---|---|---|---|
Age (years); mean ± SD | 66 ± 14 | 65 ± 13 | 0.38 |
Simplified Acute Physiology Score II; mean ± SD | 59.0 ± 15.4 | 57.2 ± 15.8 | 0.19 |
Sequential Organ Failure Assessment Score; mean ± SD | 11.06 ± 3.1 | 11.0 ± 3.1 | 0.83 |
Male sex; n (%) | 168 (66.4) | 196 (70.3) | 0.34 |
Preexisting medical conditions; n (%) | |||
Ischemic heart disease | 31 (12.3) | 28 (10) | 0.426 |
Chronic heart failure | 36 (14.2) | 42 (15.1) | 0.79 |
Chronic obstructive pulmonary disease | 32 (12.6) | 39 (14) | 0.65 |
Chronic renal failure | 21 (8.3) | 7 (2.5) | 0.003 |
Liver cirrhosis | 13 (5.1) | 18 (6.5) | 0.52 |
Diabetes | 59 (23.3) | 51/278 (18.3) | 0.16 |
Cancer or autoimmune disease | 81 (32) | 100 (35.8) | 0.35 |
Chronic arterial hypertension | 112 (44.3) | 120 (43) | 0.77 |
Source of infection; n (%) | |||
Lung | 142/249 (57) | 156/275 (56.7) | 0.95 |
Abdomen | 45/249 (18.1) | 48/275 (17.5) | 0.85 |
Urinary tract | 18/249 (7.2) | 25/275 (9.1) | 0.44 |
Other | 44/249 (17.7) | 46/275 (16.7) | 0.78 |
Hemodynamic and biochemical variables; mean ± SD | |||
Mean arterial pressure (mmHg)/n | 74 ± 14 | 73 ± 14 | 0.38 |
Arterial pH/n | 7.27 ± 0.14 | 7.28 ± 0.12 | 0.45 |
Serum lactate (mmol/L)/n | 3.84 ± 3.85 | 3.31 ± 3.26 | 0.10 |
Fluid therapy before inclusion (mL) | 2993 ± 1405 | 3068 ± 1378 | 0.55 |
Acute kidney injury, n (%)a | 86 (34) | 77 (27.6) | 0.11 |