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Table 2 Daily and global analysis of sedative drugs doses, vasopressor doses and use of neuromuscular blockers during the 5 protocol-specified days, for low- and high-target group

From: Effects of mean arterial pressure on arousal in sedated ventilated patients with septic shock: a SEPSISPAM post hoc exploratory study

Variables

Daily analysis

Global analysisa

Day

Low-target group

High-target group

P

P

Number of patients treated with vasoactive drugs; n

D0

219

248

NA

NA

D1

197

231

NA

D2

122

158

NA

D3

76

112

NA

D4

53

78

NA

D5

41

56

NA

Daily dose of norepinephrine per patient (mg/kg); mean (SD)/n

D0

37.94 (48.59)/219

57.48 (86.91)/248

0.003

 

D1

70.09 (97.34)/197

94.19 (163.35)/231

0.06

D2

63.4 (108.37)/122

57.89 (75.5)/158

0.632

D3

60.03 (98.21)/76

50.19 (78.84)/112

0.468

D4

64.39 (95.24)/53

47.3 (73.39)/78

0.273

D5

46.89 (75.02)/41

47.58 (73.36)/56

0.964

Daily dose of fentanyl per patient (µg/kg); mean (SD)/n

D0

11.04 (14.43)/209

12.22 (20.23)/236

0.476

0.665

D1

14.23 (18.48)/191

14.66 (21.55)/220

0.827

D2

11.64 (14.96)/120

14.15 (21.34)/150

0.258

D3

14.51 (17.07)/71

15.68 (21.71)/103

0.692

D4

18.12 (18.93)/51

17.07 (22.59)/71

0.781

D5

20.43 (21.8)/39

19.96 (27.76)/52

0.929

Daily dose of midazolam per patient (mg/kg); mean (SD)/n

D0

1.28 (1.39)/212

1.43 (1.33)/238

0.449

0.613

D1

1.72 (1.64)/184

1.71 (1.55)/215

0.710

D2

1.56 (1.43)/115

1.59 (1.41)/143

0.243

D3

1.81 (1.5)/70

1.61 (1.54)/104

0.584

D4

1.73 (1.45)/49

1.61 (1.57)/68

0.967

D5

1.91 (1.69)/36

2.18 (1.91)/46

0.932

Daily dose of propofol per patient (mg/kg); mean (SD)/n

D0

10.34 (19.52)/11

14.3 (21.41)/19

0.245

0.734

D1

38.61 (26.85)/8

13.88 (18.02)/13

0.01

D2

0

12.2 (15.08)/11

 

D3

0

8.16 (7.41)/7

 

D4

8.57 (0.34)/2

6.86 (8.37)/2

 

D5

6.71 (NA)/1

5.41 (5.86)/4

0.8

Patients treated with neuromuscular blockers; n (%)

D0

86/219 (39.3%)

102/248 (41.1%)

0.683

0.726

D1

73/197 (37.1%)

83/231 (35.9%)

0.81

D2

41/122 (33.6%)

45/158 (28.5%)

0.357

D3

29/76 (38.2%)

24/112 (21.4%)

0.012

D4

21/53 (39.6%)

20/78 (25.6%)

0.09

D5

21/41 (51.2%)

17/56 (30.4%)

0.038

  1. NA Not applicable, SD standard deviation
  2. aMixed generalized linear regression model, which estimated the association between treatment arm (low-/high- target group) and the studied variable (repeated measures from D0 to D5). A p value lower than 0.05 indicates an association between target group and the studied variable