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Table 2 Daily and global analysis of sedative drugs doses, vasopressor doses and use of neuromuscular blockers during the 5 protocol-specified days, for low- and high-target group

From: Effects of mean arterial pressure on arousal in sedated ventilated patients with septic shock: a SEPSISPAM post hoc exploratory study

Variables Daily analysis Global analysisa
Day Low-target group High-target group P P
Number of patients treated with vasoactive drugs; n D0 219 248 NA NA
D1 197 231 NA
D2 122 158 NA
D3 76 112 NA
D4 53 78 NA
D5 41 56 NA
Daily dose of norepinephrine per patient (mg/kg); mean (SD)/n D0 37.94 (48.59)/219 57.48 (86.91)/248 0.003  
D1 70.09 (97.34)/197 94.19 (163.35)/231 0.06
D2 63.4 (108.37)/122 57.89 (75.5)/158 0.632
D3 60.03 (98.21)/76 50.19 (78.84)/112 0.468
D4 64.39 (95.24)/53 47.3 (73.39)/78 0.273
D5 46.89 (75.02)/41 47.58 (73.36)/56 0.964
Daily dose of fentanyl per patient (µg/kg); mean (SD)/n D0 11.04 (14.43)/209 12.22 (20.23)/236 0.476 0.665
D1 14.23 (18.48)/191 14.66 (21.55)/220 0.827
D2 11.64 (14.96)/120 14.15 (21.34)/150 0.258
D3 14.51 (17.07)/71 15.68 (21.71)/103 0.692
D4 18.12 (18.93)/51 17.07 (22.59)/71 0.781
D5 20.43 (21.8)/39 19.96 (27.76)/52 0.929
Daily dose of midazolam per patient (mg/kg); mean (SD)/n D0 1.28 (1.39)/212 1.43 (1.33)/238 0.449 0.613
D1 1.72 (1.64)/184 1.71 (1.55)/215 0.710
D2 1.56 (1.43)/115 1.59 (1.41)/143 0.243
D3 1.81 (1.5)/70 1.61 (1.54)/104 0.584
D4 1.73 (1.45)/49 1.61 (1.57)/68 0.967
D5 1.91 (1.69)/36 2.18 (1.91)/46 0.932
Daily dose of propofol per patient (mg/kg); mean (SD)/n D0 10.34 (19.52)/11 14.3 (21.41)/19 0.245 0.734
D1 38.61 (26.85)/8 13.88 (18.02)/13 0.01
D2 0 12.2 (15.08)/11  
D3 0 8.16 (7.41)/7  
D4 8.57 (0.34)/2 6.86 (8.37)/2  
D5 6.71 (NA)/1 5.41 (5.86)/4 0.8
Patients treated with neuromuscular blockers; n (%) D0 86/219 (39.3%) 102/248 (41.1%) 0.683 0.726
D1 73/197 (37.1%) 83/231 (35.9%) 0.81
D2 41/122 (33.6%) 45/158 (28.5%) 0.357
D3 29/76 (38.2%) 24/112 (21.4%) 0.012
D4 21/53 (39.6%) 20/78 (25.6%) 0.09
D5 21/41 (51.2%) 17/56 (30.4%) 0.038
  1. NA Not applicable, SD standard deviation
  2. aMixed generalized linear regression model, which estimated the association between treatment arm (low-/high- target group) and the studied variable (repeated measures from D0 to D5). A p value lower than 0.05 indicates an association between target group and the studied variable