Association between post-procedural hyperoxia and poor functional outcome after mechanical thrombectomy for ischemic stroke: an observational study

López, Héctor Vargas; Vivas, Miguel Fernández; Ruiz, Rafael Núñez; Martínez, José Ros; Navaridas, Blanca García-Villalba; Villa, Manuel García; Lázaro, Cristina Llamas; Rubio, Rubén Jara; Ortiz, Ana Morales; Lacal, Laura Albert; Diéguez, Antonio Moreno

doi:10.1186/s13613-019-0533-8

Annals of Intensive Care

Table 1 Characteristics of patients at ICU admission

From: Association between post-procedural hyperoxia and poor functional outcome after mechanical thrombectomy for ischemic stroke: an observational study

Characteristic	pO2 ≤ 120 mmHg N = 214	pO2 > 120 mmHg N = 119	Significance level (p value)
Age in years	71 (60–78)	71 (57–77)	0.49
Male sex	107 (50.0)	55 (46.2)	0.51
Body mass index	27 (25–30)	26 (24–28)	0.02
History of smoking	66 (30.8)	31 (26.1)	0.36
Baseline Rankin			0.95
0	151 (70.9)	86 (72.3)	0.79
1	44 (20.7)	19 (16.0)	0.30
≥ 2	18 (8.5)	14 (11.8)	0.33
Hypertension	150 (70.1)	75 (63.0)	0.19
Dyslipidemia	96 (44.9)	48 (40.3)	0.42
Diabetes mellitus	61 (28.5)	34 (28.6)	0.99
History of COPD^a	19 (8.9)	7 (5.9)	0.33
History of CRF^b	12 (5.6)	7 (5.9)	0.92
Atrial fibrillation/flutter	88 (41.1)	45 (37.8)	0.55
Previous stroke	26 (12.1)	12 (10.1)	0.57
Previous antiaggregating therapy	64 (29.9)	39 (32.8)	0.59
Previous anticoagulation therapy	35 (16.4)	18 (15.1)	0.77
Preprocedure GCS	14 (13–15)	14 (12–15)	0.44
Preprocedure NIHSS	18 (12–21)	19 (14–22)	0.09
APACHE	15 (12–19)	16 (12–22)	0.23
Findings in CT scan			0.11
Without ischemia	80 (38.1)	53 (44.5)	0.25
Acute ischemic areas^c	103 (49.0)	59 (49.6)	0.93
Areas of ancient stroke	27 (12.9)	7 (5.9)	0.05
Mismatch	70 (50–80)	70 (50–80)	0.43
Etiology of stroke			0.01
Cardioembolic	96 (44.9)	34 (28.6)	< 0.01
Atherothrombotic	69 (32.2)	48 (40.3)	0.14
Idiopathic	49 (22.9)	37 (31.1)	0.10
Wake-up stroke	25 (11.7)	12 (10.1)	0.66
Time (min.) onset of symptoms—IAMT	270 (210–367)	300 (220–398)	0.24
Type of intervention			0.85
Thrombectomy	180 (84.1)	101 (84.9)
Thrombectomy + stent	34 (15.9)	18 (15.1)
Reperfusion degree^e			0.18
Successful reperfusion	201 (93.9)	107 (89.9)
Non-successful reperfusion	13 (6.1)	12 (10.1)
OTI at admission^e	97 (45.3)	79 (66.4)	< 0.01
MAP^f	87 (73–98)	90 (77–103)	0.22

This table value of quantitative variables expressed as median and interquartile range. Values of qualitative variables expressed as n (%)
^aChronic obstructive pulmonary disease
^bCreatinine clearance < 60 ml/min/1.73 m²
^cIncluded signs of acute ischemia and indirect signs of ischemia: hyperdense middle cerebral artery sign, hemispheric sulcus and/or insular cortex effacement, contrast attenuation, ventricular compression
^dSuccessful reperfusion included TICI 2b and TICI 3. Non-successful reperfusion includes TICI ≤ 2a
^ePatients intubated at ICU admission after IAMT
^fMean arterial pressure at ICU admission after IAMT

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