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Table 2 Change from screening to hour 48 in total SOFA score and CV SOFA score

From: Sensitivity to angiotensin II dose in patients with vasodilatory shock: a prespecified analysis of the ATHOS-3 trial

  Angiotensin II > 5 ng kg−1 min−1 (n = 84) Angiotensin II ≤ 5 ng kg−1 min−1 (n = 79) P value
Total SOFA score
 Mean (SD) 2.6 (5.5) − 0.6 (5.0) 0.002a
 Median (range) 1.0 (− 6 to 15) − 2.0 (− 10 to 15)  
CV SOFA scoreb
 Mean (SD) − 1.33 (1.7) − 2.2 (1.7) 0.004
 Median (range) 0.0 (− 4 to 0) − 3.0 (–4 to 0)  
  1. CV, cardiovascular; MAP, mean arterial pressure; SOFA, Sequential Organ Failure Assessment; SD, standard deviation
  2. avan Elteren Wilcoxon rank test of angiotensin II dose at 30 min stratified by randomization strata for MAP and APACHE II score
  3. bAll patients had a CV SOFA score of 4 (highest risk) at screening based on inclusion/exclusion criteria. For patients missing a 48-hour assessment, the last observation was carried forward. In the event of death prior to the 48-hour assessment, the patient was assigned a CV SOFA score of 4. The van Elteren Wilcoxon rank test compared angiotensin II with placebo adjusting for randomization strata for MAP and APACHE II score