|
Angiotensin II > 5 ng kg−1 min−1 (n = 84)
|
Angiotensin II ≤ 5 ng kg−1 min−1 (n = 79)
|
P value
|
---|
Total SOFA score
|
Mean (SD)
|
2.6 (5.5)
|
− 0.6 (5.0)
|
0.002a
|
Median (range)
|
1.0 (− 6 to 15)
|
− 2.0 (− 10 to 15)
| |
CV SOFA scoreb
|
Mean (SD)
|
− 1.33 (1.7)
|
− 2.2 (1.7)
|
0.004
|
Median (range)
|
0.0 (− 4 to 0)
|
− 3.0 (–4 to 0)
| |
- CV, cardiovascular; MAP, mean arterial pressure; SOFA, Sequential Organ Failure Assessment; SD, standard deviation
- avan Elteren Wilcoxon rank test of angiotensin II dose at 30 min stratified by randomization strata for MAP and APACHE II score
- bAll patients had a CV SOFA score of 4 (highest risk) at screening based on inclusion/exclusion criteria. For patients missing a 48-hour assessment, the last observation was carried forward. In the event of death prior to the 48-hour assessment, the patient was assigned a CV SOFA score of 4. The van Elteren Wilcoxon rank test compared angiotensin II with placebo adjusting for randomization strata for MAP and APACHE II score