Inflammatory anemia-associated parameters are related to 28-day mortality in patients with sepsis admitted to the ICU: a preliminary observational study

Annals of Intensive Care

Table 5 Performance of inflammatory anemia-associated parameters and SOFA score on day 1 of ICU admission for predicting 28-day mortality in patients with sepsis

	Cutoff	Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)	Youden (%)	LR+	LR–
EPO	52.6 IU/L	83.0	68.2	67.6	83.3	51.1	2.61	0.25
Hepcidin	142.6 ng/mL	65.9	87.3	80.6	76.2	53.2	5.19	0.39
Ferritin	207.2 ng/mL	69.3	70.0	64.9	74.0	39.3	2.31	0.44
IL-6	89.1 pg/mL	73.9	66.4	63.7	76.0	40.2	2.20	0.39
RDW	13.7%	86.4	49.1	57.6	81.8	35.5	1.70	0.28
sTfR/log ferritin	8.4 nmol/L	58.0	81.8	71.8	70.9	39.8	3.19	0.51
SOFA score	8.5	78.4	80.0	75.8	82.2	58.4	3.92	0.27

EPO erythropoietin; ICU intensive care unit; IL-6 interleukin-6; LR + positive likelihood ratio; LR– negative likelihood ratio; NPV negative predictive value; PPV positive predictive value; RDW red blood cell distribution width; SOFA Sequential Organ Failure Assessment; sTfR soluble transferrin receptor