Table 2 Ongoing or completed clinical studies of ECCO2R in COPD
From: Extracorporeal carbon dioxide removal for acute hypercapnic respiratory failure
ClinicalTrials.gov number | Title | Type of study | Hypothesis/primary outcome | Estimated enrollment | Device | Status |
|---|---|---|---|---|---|---|
ECCO2R to avoid mechanical ventilation | ||||||
 NCT02564406 | Extracorporeal CO2 removal in hypercapnic patients | Interventional single-group trial | Retrospectively assess the efficacy and safety of noninvasive ventilation-plus-extracorporeal CO2 removal in patients who fail NIV and refuse endotracheal intubation Primary outcome: Number of patients who avoided endotracheal intubation | 35 patients | ProLUNG [Estor] | Completed |
 NCT03692117 |  | Prospective cohort study | Primary outcome: Incidence of avoiding endotracheal intubation | 30 patients | Not specified | Recruiting |
ECCO2R as an alternative or adjunct to invasive mechanical ventilation | Â | |||||
 NCT03255057 | Extracorporeal CO2 removal for mechanical ventilation avoidance during acute exacerbation of COPD (VENT-AVOID) | Multicenter randomized controlled trial | ECCO2R can be safely used to avoid or reduce time on invasive mechanical ventilation compared to COPD patients treated with standard-of-care mechanical ventilation alone Primary outcome: Ventilator-free days at day 60 from randomization | 500 patients | Hemolung | Recruiting |
ECCO2R physiological studies | Â | |||||
 NCT02586948 | Physiological study of minimally invasive ECCO2R in exacerbations of COPD requiring invasive mechanical ventilation (EPHEBE) | Interventional single-group trial | The addition of minimally invasive ECCO2R is likely to limit dynamic hyperinflation in COPD patients requiring invasive mechanical ventilation for an acute exacerbation while improving gas exchange Primary outcome: PEEPi at baseline and after ECCO2R by the device and adjustment of ventilator settings, expressed in cmH20 | 12 patients | Hemolung | Completed |
 NCT02590575 |  | Interventional single-group trial | Test the effectiveness of a membrane gas exchange device in the veno-venous circulation of continuous renal replacement therapy for the purpose of CO2 elimination and pH compensation The primary outcome is the modification of the PaCO2 and/or the ventilator settings (tidal volume VT and plateau pressure Pplat) | 20 patients | Prismalung | Completed |