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Table 2 Measurements of respiratory function and hemodynamics (n = 19)

From: PEEP titration in moderate to severe ARDS: plateau versus transpulmonary pressure

Protocols PEEPbaseline Express protocol P Lexpi p value
PEEP (cmH2O) 7.0 ± 1.8 14.2 ± 3.6* 16.7 (5.9)* < 0.0001
Pplat (cmH2O) 20.8 ± 4.0 28.8 ± 2.0 * 33.9 ± 10.6* < 0.0001
PL,es (cmH2O) 7.0 ± 5.9 11.9 ± 6.2* 15.5 ± 8.5* 0.0013
PL,EL (cmH2O) 15.3 ± 4.9) 20.5 ± 4.7* 24.3 ± 11.4* 0.0025
PLexpi (cmH2O) − 2.6 ± 5.2 1.4 ± 5.1* 3.3 ± 1.6* < 0.0001
EELV (ml) 1546 ± 634 2067 ± 924* 2287 ± 945* 0.001
DPaw (cmH2O) 13.0 ± 3.9 14.2 ± 5.0 16.4 ± 7.8 0.17
DPL (cmH2O) 9.9 ± 4.4 10.6 ± 5.6 12.3 ± 8.3 0.20
DPL,EL (cmH2O) 7.5 ± 4.3 8.1 ± 5.6 9.5 ± 8.1 0.30
Crs (ml/cmH2O) 33.3 ± 15.8 30.0 ± 10.7 28.3 ± 13.2 0.17
Ecw (cmH2O/l) 8.7 ± 2.7 9.6 ± 3.4* 10.9 ± 4.3* 0.03
EL (cmH2O/l) 26.0 ± 11.9 28.0 ± 15.9 33.2 ± 25.1 0.25
FiO2 (%) 80.0 ± 21.1 80.6 ± 21.2 81.1 ± 21.6 0.46
PaO2/FiO2 91.2 ± 31.2 134.0 ± 67.2* 152.7 ± 80.1* 0.01
pH 7.31 ± 0.11 7.30 ± 0.11 7.31 ± 0.12 0.08
PaCO2 (mmHg) 45.2 ± 10.4 46.5 ± 9.6 45.3 ± 11.0 0.26
MAP (mmHg) 82.0 ± 13.4 74.7 ± 12.9 75.7 ± 12.0 0.06
Heart rate (beats/min) 99 ± 27 102 ± 26 107 ± 28 0.19
Lactates (mmol/l) 1.6 ± 0.9 1.5 ± 0.8 1.5 ± 0.8 0.27
  1. Results are expressed as mean ± standard deviation
  2. Pplat: plateau pressure; PLexpi: end-expiratory transpulmonary pressure; DPL: transpulmonary driving pressure; PL,EL: relative end-expiratory pressure; PL,es: absolute inspiratory transpulmonary pressure; DPaw: airway driving pressure; DPL: transpulmonary driving pressure, DPL,EL: transpulmonary elastance-related driving pressure; EL: lung elastance; EELV: end-expiratory lung volume; Ecw: elastance chest wall; Crs: compliance respiratory system; MAP: mean arterial pressure. p value refers to repeated measures ANOVA. *p < 0.05 of Express and PLexpi groups versus baseline group. §p < 0.05 of Express versus PLexpi groups