Long-term neurocognitive outcome is not worsened by of the use of venovenous ECMO in severe ARDS patients

Sylvestre, Aude; Adda, Mélanie; Maltese, François; Lannelongue, Ariane; Daviet, Florence; Parzy, Gabriel; Coiffard, Benjamin; Roch, Antoine; Loundou, Anderson; Baumstarck, Karine; Papazian, Laurent

doi:10.1186/s13613-019-0556-1

Annals of Intensive Care

Table 2 Characteristics of the patients during the ICU stay

From: Long-term neurocognitive outcome is not worsened by of the use of venovenous ECMO in severe ARDS patients

Characteristic	Non-ECMO (n = 18)	ECMO (n = 22)	p Value
MV duration before ARDS, days	2 [0–5]	0.5 [0–5]	0.66
MV duration before ECMO, days	–	4 [1–9]
Lung Injury Score at day 1	3 [2.5–3.1]	3 [2.8–3.4]	0.23
Lowest PaO₂ at day 1, mmHg	69 [62–79]	73 [52–81]	0.93
Lactate level at day 1 (mmol/L)	2.3 [1.4–3.1]	2.2 [1.4–3.1]	0.99
Duration of hypoxemia (PaO₂ < 50 mmHg), hours	2 [1–5]	6 [3–8]	0.026
Duration of hypoxemia (PaO₂ < 65 mmHg), hours	10 [6–31]	31 [9–54]	0.09
Days of PEEP > 10 cm H₂O	13 [8–17]	16 [14–30]	0.022
Adjunctive therapies
Nitric oxide, n (%)	6 (33)	11 (50)	0.29
Prone positioning, n (%)	17 (94)	17 (77)	0.20
Days receiving benzodiazepines	14 [11–18]	25 [21–34]	< 0.001
Days receiving narcotics	14 [11–20]	26 [22–35]	< 0.001
Days receiving neuromuscular blockade	7 [3–10]	11 [7–15]	0.022
Days receiving neuroleptics	4 [1–7]	4 [0–11]	0.90
Days receiving vasopressors	7 [3–16]	12 [8–16]	0.08
Delirium during ICU, n (%)	12 (67)	12 (55)	0.44
Renal replacement therapy, n (%)	5 (27.8)	6 (27.3)	0.99
Transfusion, n (%)	16 (89)	22 (100)	0.20
Any systemic glucocorticoid therapy, n (%)	12 (67)	17 (77)	0.46
Septic shock, n (%)	5 (42)	9 (53)	0.55
ARDS, n (%)	1 (8)	6 (35)	0.19
Other, n (%)	6 (50)	5 (29)	0.26
No. VAP	0 [0–1]	1 [0–2]	0.6
No. episodes blood glucose < 3.5 mmol/L	0 [0–2]	0 [0–2]	0.93
Natremia < 135 mmol/L, days	3 [1–8]	1 [1–6]	0.33
Natremia > 146 mmol/L, days	4 [2–6]	5 [1–7]	0.78
Cumulative 7-days fluid balance, L	12.5 [7.3–16.4]	12.8 [9.31–22.2]	0.31
MRC neuromuscular score at discharge	42 [33–46]	39 [33–48]	0.70
Duration of ECMO support, days	–	12 [8–19]
Duration of MV total, days	29 [21–46]	36 [28–64]	0.16
ICU LOS, days	35 [24–47]	46 [34–71]	0.08
Hospital LOS, days	55 [43–90]	61 [45–99]	0.77
Time to return back to home, days	93 [57–123]	120 [72–158]	0.13

Data are provided as numbers (%) for categorical variables and as medians [25th–75th percentiles] for continuous variables
MV Mechanical ventilation, ECMO extracorporeal membrane oxygenation, LOS length of stay, PEEP positive end-expiratory pressure, ICU intensive care unit, ARDS acute respiratory distress syndrome, VAP ventilator-acquired pneumonia, MRC Medical Research Council

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