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Table 3 Subgroup analyses

From: Impact of furosemide on mortality and the requirement for renal replacement therapy in acute kidney injury: a systematic review and meta-analysis of randomised trials

Subgroup analysis  Description Mortality Requirement for RRT
Fixed effect model Random effect model Fixed effect model Random effect model
By intervention Prevention OR = 0.852 (95% CI 0.303–2.395), p = 0.7 OR = 0.780 (95% CI 0.235–2.590), p = 0.7 OR = 0.584 (95% CI 0.210–1.625), p = 0.3 OR = 0.678 (95% CI 0.133–3.450), p = 0.6
Treatment OR = 1.063 (95% CI 0.832–1.359), p = 0.6 OR = 1.065 (95% CI 0.831–1.364), p = 0.6 OR = 0.904 (95% CI 0.625–1.413), p = 0.8 OR = 1.037 (95% CI 0.568–1.894), p = 0.9
By AKI aetiology Cardio-renal syndrome OR = 1.108 (95% CI 0.734–1.674), p = 0.6 OR = 1.114 (95% CI 0.733–1.692), p = 0.6
CIN OR = 0.381 (95% CI 0.07–1.996), p = 0.2 OR = 0.385 (95% CI 0.07–2.031), p = 0.3 OR = 0.211 (95% CI 0.04–0.99), p = 0.049 OR = 0.218 (95% CI 0.05–1.04), p = 0.055
Post-CPB OR = 1.688 (95% CI 0.388–7.345), p = 0.5 OR = 1.5115 (95% CI 0.178–12.869), p = 0.7 OR = 4.147 (95% CI 0.449–38.27), p = 0.2 OR = 4.075 (95% CI 0.437–38.02), p = 0.2
Critical illness (ICU patients) OR = 1.039 (95% CI 0.765–1.411), p = 0.8 OR = 1.039 (95% CI 0.764–1.413), p = 0.8 OR = 0.940 (95% CI 0.625–1.413), p = 0.8 OR = 1.037 (95% CI 0.568–1.894), p = 0.9
By control arm treatment RRT OR = 1.169 (95% CI 0.778–1.757), p = 0.4 OR = 1.169 (95% CI 0.775–1.766), p = 0.4
Saline/placebo/standard of care OR = 0.618 (95% CI 0.304–1.256), p = 0.2 OR = 0.626 (95% CI 0.197–1.994), p = 0.4 OR = 1.397 (95% CI 0.736–2.652), p = 0.3 OR = 1.393 (95% CI 0.711–2.730), p = 0.3
By daily furosemide dose < 160 mg OR = 0.931 (95% CI 0.651–1.329), p = 0.7 OR = 0.923 (95% CI 0.642–1.326), p = 0.7 OR = 0.727 (95% CI 0.466–1.134), p = 0.2 OR = 0.703 (95% CI 0.315–1.568), p = 0.4
≥ 160 mg OR = 1.194 (95% 0.848–1.680), p = 0.3 OR = 1.201 (95% CI 0.850–1.695), p = 0.3
  1. AKI acute kidney injury, CI confidence interval, CIN contrast-induced nephropathy, CPB cardiopulmonary bypass, ICU intensive care unit, OR odds ratio, RRT renal replacement therapy