Table 3 Main causes of hyperlactatemia suggested by the experts (EXPERT OPINION)
From: Diagnosis and management of metabolic acidosis: guidelines from a French expert panel
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Type A Severe anemia Septic, hemorrhagic, cardiogenic shock CO poisoning Organ ischemia Convulsions Intense physical exercise |
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Type B Sub-type B1—Underlying primary diseases Cancer and hemopathy Decompensated diabetes HIV infection Liver failure Sepsis Severe malaria attack Sub-type B2—Medication and toxins Alcohol Beta-adrenergic agents Cyanide and cyanogenic compounds Diethyl ether Fluorouracil (5-FU) Halothane Iron Isoniazid Linezolid Metformin Nalidixic acid Niacin (vitamin B3 or nicotinic acid) Nucleoside reverse transcriptase inhibitors Paracetamol Propofol Psychostimulants: cocaine, amphetamines, cathinones Salicylates Strychnine Sugars: fructose, sorbitol, xylitol Sulfasalazine Total parenteral nutrition Valproic acid Vitamin deficiency: thiamine (vitamin B1) and biotin (vitamin B8) Sub-type B3—Inborn errors of metabolism Fructose-1,6-diphosphatase deficiency Glucose-6-phosphatase deficiency (von Gierke disease) Kearns–Sayre syndrome MELAS syndrome MERRF syndrome Methylmalonic acidemia (methylmalonyl-CoA mutase deficiency) Pearson syndrome Pyruvate carboxylase deficiency Pyruvate dehydrogenase deficiency |