Table 1 Characteristics and outcomes of patients with and without hyperchloremia
Not included patients N = 21 | No hyperchloremia N = 156 | Hyperchloremia N = 257 | P valuea | |
|---|---|---|---|---|
Hypertonic saline group, n (%) | 13 (62) | 45 (29) | 156 (61) | < 0.001 |
Age, year | 64 (61–73) | 68 (57–77) | 69 (59–78) | 0.28 |
Mc Cabe, n (%) | 0.36 | |||
No fatal underlying disease | 14 (67) | 94 (60) | 171 (67) | |
Fatal underlying disease at 5 year | 6 (29) | 44 (17) | 65 (25) | |
Fatal underlying disease at 1 year | 1 (5) | 18 (12) | 21 (8) | |
Sex M, n (%) | 11 (52) | 108 (69) | 158 (61) | 0.11 |
Weight, Kg | 67 (59–80) | 73 (61–85) | 70 (61–80) | 0.32 |
Surgical admission, n (%) | 6 (29) | 32 (21) | 89 (35) | 0.002 |
Cumulative volume of fluids before H0, L | 2.5 (2.3–4.0) | 2.5 (2.0–3.5) | 2.8 (2.0–3.6) | 0.28 |
History of, n (%) | ||||
CKD | 3 (14) | 19 (12) | 24 (9) | 0.35 |
Cirrhosis | 2 (10) | 6 (4) | 12 (5) | 0.70 |
Heart failure | 0 | 9 (6) | 14 (5) | 0.88 |
Immunosuppression | 5 (24) | 31 (20) | 51 (20) | 0.99 |
Diabetes | 4 (19) | 33 (21) | 49 (19) | 0.58 |
Serum Creatinine at H0, µmol/Lb | 180 (135–241) | 133 (79–195) | 130 (79–189) | 0.21 |
ARDS at H0, n (%) | 5 (24) | 41 (26) | 69 (27) | 0.90 |
SAPS II, points | 69 (55–79) | 55 (46–63) | 56 (48–65)° | 0.18 |
SOFA at H0, points | 11 (9–16) | 10 (8–12) | 10 (8–12) | 0.31 |
Vasopressor dose at H0, µg/Kg/min | 0.45 (0.28–1.0) | 0.32 (0.20–0.66) | 0.44 (0.23–0.80) | 0.04 |
Cumulative volume of fluids for resuscitation H0–H72, L | 1.4 (0.6–2.2) | 1.4 (0.6–2.3) | 2.2 (1.1–3.9) | <0.001 |
Outcomes, n (%) | ||||
AKI | 7 (33) | 71 (51) | 110 (45) | 0.29 |
Need for RRTb | 7 (33) | 53 (36) | 90 (36) | 0.98 |
Make 28 | 15 (71) | 83 (53) | 131 (51) | 0.66 |
Day-28 mortality | 15 (71) | 60 (38) | 95 (37) | 0.76 |