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Table 2 Uni and multivariate analysis for chloride parameters and AKI

From: Hyperchloremia is not associated with AKI or death in septic shock patients: results of a post hoc analysis of the “HYPER2S” trial

 

No AKI

N = 203

AKI

N = 181

HR 95% CI, p

Adjusted HR a,b95% CI, p

Hyper chloremia, n (%)

 No

69 (34.0%)

71(39.2%)

1 (ref)

1 (ref)

 Yes

134 (66.5%)

110 (60.8%)

0.94 [0.67; 1.31], 0.706

1.01 [0.66; 1.52], 0.974

[Chloride], mmol/L

1.00 [0.98; 1.03], 0.647

1.01 [0.99; 1.03], 0.872

[Chloride] max, mmol/L

112 [107–119]

111 [108 – 117]

1.00 [0.98; 1.02], 0.962

1.00 [0.98; 1.02], 0.792

Delta [Chloride] > 5 mmol/L, n (%)

 No

93 (46.5%)

70 (45.2%)

1 (ref)

 

 Yes

107 (53.5%)

85 (54.8%)

1.04 [0.73;1.48], 0.851

0.94 [0.66; 1.34], 0.724

[Na–Cl] difference, mmol/L

1.00 [0.99; 1.02], 0.852

1.00 [0.98; 1.03], 0.914

[Na–Cl] minimal difference, mmol/L

30 [28–33]

30 [27–33]

0.99 [0.96; 1.04], 0.834

1.01 [0.96; 1.05], 0.830

  1. aAdjusted for SAPS, surgical admission, weigh, chronic kidney disease, diabetes, SOFA and ARDS at H0 and for the following time-dependent variables: serum creatinine, vasopressor dose, volume of fluid resuscitation
  2. bAdjusted models were developed in the 340 patients free of RRT at inclusion and without missing data