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Table 3 Uni and multivariate analysis for chloride parameters and mortality

From: Hyperchloremia is not associated with AKI or death in septic shock patients: results of a post hoc analysis of the “HYPER2S” trial

 

Survivors

N = 258

Non survivors

N = 155

HR 95% CI, p

Adjusted HRa, # 95% CI, p

Hyper chloremia, n (%)

 No

96 (37.2%)

60 (38.7%)

 

1 (ref)

 Yes

162 (62.8%)

95 (61.3%)

0.87 [0.61;1.27], 0.509

0.88 [0.96; 1.00], 0.061

[Chloride], mmol/l

0.98 [0.96; 1.00], 0.193

0.99 [0.97; 1.01], 0.175

[Chloride] max, mmol/L

112 [107–118]

111 [106.5–117]

0.99 [0.97;1.01], 0.363

0.98 [0.96; 0;99], 0.043

Delta [Chloride] > 5 mmol/L, n

 No

103 (44.8%)

67 (48.2%)

1 (ref)

1 (ref)

 Yes

127 (55.2%)

72 (51.8%)

0.88 [0.61; 1.26], 0.492

0.72 [0.49; 1.04], 0.081

[Na–Cl] difference, mmol/L

1.00 [0.93; 1.08], 0.942

1.00 [0.93; 1.09], 0.924

[Na–Cl] minimal difference, mmol/L

30 [28–32]

30 [27–34]

1.02 [0.98; 1.07], 0.285

1.03 [0.98; 1.08], 0.286

  1. aAdjusted for hyperoxia group, age, MacCabe, SAPS, SOFA, Hyperlactatemia, Serum creatinine and ARDS at H0 and for the following time-dependent variable: Serum creatinine, vasopressor dose, Serum lactate and volume of fluid resuscitation
  2. #Adjusted models were developed in the 352 patients without missing data