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Table 3 Biomarker levels in all patients and according to development of acute kidney injury

From: Association of endothelial and glycocalyx injury biomarkers with fluid administration, development of acute kidney injury, and 90-day mortality: data from the FINNAKI observational study

Biomarker level (ng/mL) at 0 h (median [IQR])

All patients (n = 619)

No AKI (n = 303)

AKI > 12 h (n = 112)

p value

Syndecan-1

109.00 [62.30–215.40]

91.40 [55.30–157.30]

125.25 [67.60–232.68]

0.004

Angiopoietin-2

6.31 [3.39–12.13]

5.53 [2.99–9.92]

7.44 [4.29–13.22]

0.028

Soluble Thrombomodulin

5.30 [4.02–7.13]

4.61 [3.69–5.97]

5.84 [4.37–7.94]

< 0.001

Vascular adhesion protein-1

241.00 [171.00–340.00]

255.00 [177.00–356.00]

241.50 [170.75–340.00]

0.889

Interleukin-6

0.57 [0.14–4.74]

0.36 [0.12–3.06]

0.83 [0.17–5.10]

0.011

  1. AKI > 12 h; AKI diagnosed over 12 h from ICU admission to day 5 or ICU discharge, if earlier