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Table 3 Nephrotoxic drugs most frequently prescribed among exposed patients

From: Nephrotoxic drug burden among 1001 critically ill patients: impact on acute kidney injury

Drugs

n = 617

Iodinated contrast media

154 (25%)

Diuretics

356 (58%)

 Loop diuretics

346 (97%)

 Thiazide diuretics

18 (5%)

 Potassium sparing diuretics

10 (3%)

Antibiotics

227 (37%)

 Vancomycin

77 (34%)

 Aminoglycosides

139 (61%)

 High-dose beta-lactams

57 (25%)

 Sulfamethoxazole trimethoprim

25 (11%)

 Rifampicin

12 (5%)

Antiviral agents

58 (9%)

 Acyclovir

36 (62%)

 Other

22 (38%)

Antifungal agents

27 (4%)

 Amphotericin B

9 (33%)

 Voriconazole

12 (44%)

 Other

6 (22%)

Renin–angiotensin–aldosterone antagonists

96 (16%)

Hydroxy-ethyl-starch

2 (< 0.5%)

Mannitol

5 (< 0.5%)

Non-steroidal anti-inflammatory drugs (including acetylsalicylic acid)

84 (14%)

Immunosuppressants and chemotherapy

16 (3%)

Other

56 (9%)

  1. Data are presented as counts (percentage). Percentages are calculated among patients receiving at least one nephrotoxic prescription during the first 7 days in the intensive-care unit and within each drug class