Morpho-functional evaluation of lung aeration as a marker of sickle-cell acute chest syndrome severity in the ICU: a prospective cohort study

Garnier, Marc; Hafiani, El Mahdi; Arbelot, Charlotte; Blayau, Clarisse; Labbe, Vincent; Stankovic-Stojanovic, Katia; Lionnet, François; Bonnet, Francis; Fulgencio, Jean-Pierre; Fartoukh, Muriel; Quesnel, Christophe

doi:10.1186/s13613-019-0583-y

Annals of Intensive Care

Table 2 Patient characteristics at inclusion

From: Morpho-functional evaluation of lung aeration as a marker of sickle-cell acute chest syndrome severity in the ICU: a prospective cohort study

Patient characteristics	All patients (n = 56)	Patients with		p
		Favourable outcome	Complicated outcome
		(n = 42)	(n = 14)
Acute chest syndrome symptoms, % (n)
Cough	70% (39)	69% (29)	71% (10)	0.17
Expectoration	50% (28)	52% (22)	43% (6)	0.54
Acute dyspnea	82% (46)	86% (36)	71% (10)	0.23
Mild	35% (16/46)	33% (12/36)	40% (4/10)	0.24
Moderate	41% (19/46)	47% (17/36)	20% (2/10)
Severe	24% (11/46)	19% (7/36)	40% (4/10)
Fever	84% (47)	83% (35)	86% (12)	0.83
Pulmonary rales	95% (53)	95% (40)	93% (13)	0.73
Crackling sounds	75% (40/53)	78% (31/40)	69% (9/13)
Acute chest pain	93% (52)	93% (39)	93% (13)	1.00
Numeric pain scale value	7 [6–9]	8 [6–9]	7 [5.3–8.5]	0.39
Other pain	68% (38)	67% (28)	71% (10)	0.74
Arms and/or legs	48% (27)	45% (19)	57% (8)	0.36
Back	23% (13)	24% (10)	21% (3)
Abdomen	9% (5)	7% (3)	14% (2)
Head and neck	5% (3)	5% (2)	7% (1)
Clinical characteristics, median [IQR]
Heart rate (/min)	100 [87–111]	99 [86- 111]	102 [88–113]	0.73
Systolic blood pressure (mmHg)	130 [115–139]	130 [112–140]	125 [122–138]	0.93
Diastolic blood pressure (mmHg)	65 [59–75]	68 [59–75]	63 [61–69]	0.79
Respiratory rate (/min)	24 [20–29]	23 [20–29]	27 [23–31]	0.16
Inspiratory vital capacity (mL)	1000 [600–1250]	1000 [600–1300]	750 [500–1100]	0.12
SOFA score (points)	4 [3–4]	3 [3–4]	4 [3–4]	0.30
SAPS II (points)	15 [10.5–17]	14 [10–17]	16 [13–18]	0.32
Laboratory values, median [IQR]^a
Haemoglobin (g/dL)	7.5 [6.9–8.5]	7.5 [6.9–8.7]	7.4 [6.5–7.8]	0.18
Haemoglobin S (%)	81 [61–88]	80 [57–87]	83 [76–88]	0.21
Platelets (G/L)	327 [298–403]	329 [264–403]	325 [294–434]	0.76
Lactate dehydrogenase (UI/L)	544 [420–745]	503 [403–715]	613 [525–834]	0.09
Total bilirubin (µmol/L)	47 [33–79]	55 [38–79]	36 [29–44]	0.06
Aspartate aminotranferase (UI/L)	58 [36–73]	53 [38–69]	69 [35–77]	0.56
Alanine aminotransferase (UI/L)	33 [18–52]	32 [18- 49]	35 [18–51]	0.87
Blood gas results, median [IQR]^b
pH	7.39 [7.36–7.41]	7.39 [7.36–7.41]	7.38 [7.35–7.42]	0.71
PaO₂ (mmHg)	81 [62–100]	80 [57–93]	96 [72–102]	0.18
With delivered O₂ flow (L/min)	3 [2–4.5]	3 [2–4.8]	3 [2–4]
PaO₂/FiO₂ ratio (mmHg)	259 [217–302]	254 [214–277]	300 [229–317]	0.19
PaCO₂ (mmHg)	44 [40–48]	43 [41–48]	47 [39–49]	0.54
SaO₂ (%)	95 [93–97.2]	95 [90–97]	97 [93.9–97.6]	0.27

SOFA score Sequential Organ Failure Assessment score, SAPS II Simplified Acute Physiologic Score II
^aBiological data available for the 56 patients, except for haemoglobin S available for 41/56 patients (29 with a favourable outcome and 12 with a complicated outcome)
^bBlood gas results available for 53 patients (39 with a favourable outcome and 14 with a complicated outcome)

Back to article page