Early intubation N = 92 | Late intubation N = 29 | p | |
---|---|---|---|
Age, years | 72.5 ± 9.8 | 76.0 ± 9.1 | 0.09 |
Male | 73 (79.3%) | 22 (75.9%) | 0.80 |
APACHE II score | 21.4 ± 5.4 | 22.3 ± 5.9 | 0.45 |
Underlying disease | |||
Diabetes mellitus | 16 (17.4%) | 4 (13.8%) | 0.78 |
Hypertension | 34 (37.0%) | 13 (44.8%) | 0.51 |
Chronic heart disease | 23 (25.0%) | 8 (27.6%) | 0.81 |
Chronic kidney disease | 10 (10.9%) | 4 (13.8%) | 0.74 |
Chronic liver disease | 10 (10.9%) | 3 (10.3%) | > 0.99 |
Data collected before NIV | |||
Respiratory rate, breaths/min | 30 ± 7 | 28 ± 7 | 0.20 |
Heart rate, beats/min | 121 ± 25 | 117 ± 26 | 0.39 |
Systolic blood pressure, mmHg | 139 ± 31 | 135 ± 32 | 0.55 |
Diastolic blood pressure, mmHg | 80 ± 18 | 78 ± 18 | 0.60 |
pH | 7.22 ± 0.08 | 7.23 ± 0.08 | 0.66 |
PaCO2, mmHg | 85 ± 23 | 82 ± 19 | 0.55 |
PaO2/FiO2, mmHg | 192 ± 107 | 178 ± 77 | 0.50 |
GCS | 12.6 ± 3.2 | 13.1 ± 2.8 | 0.47 |
Data collected at 1–2 h of NIV | |||
Respiratory rate, breaths/min | 28 ± 7 | 26 ± 7 | 0.15 |
Heart rate, beats/min | 117 ± 26 | 109 ± 24 | 0.11 |
Systolic blood pressure, mmHg | 132 ± 34 | 125 ± 18 | 0.25 |
Diastolic blood pressure, mmHg | 78 ± 19 | 74 ± 13 | 0.30 |
Minute ventilation, L/min | 8.9 ± 4.1 | 9.8 ± 4.7 | 0.33 |
IPAP, cmH2O | 17 ± 4 | 17 ± 5 | 0.89 |
EPAP, cmH2O | 5 ± 2 | 6 ± 1 | 0.50 |
pH | 7.21 ± 0.11 | 7.27 ± 0.09 | < 0.01* |
PaCO2, mmHg | 90 ± 28 | 76 ± 20 | 0.02* |
PaO2/FiO2, mmHg | 164 ± 88 | 169 ± 64 | 0.79 |
GCS | 11.5 ± 3.4 | 13.2 ± 2.0 | 0.01* |
HACOR score before NIV | 9.4 ± 3.7 | 8.9 ± 4.0 | 0.54 |
HACOR score at 1–2 h of NIV | 13.9 ± 5.6 | 9.3 ± 3.4 | < 0.01* |
ICU mortality | 33 (35.9%) | 23 (79.3%) | < 0.01* |
Hospital mortality | 33 (35.9%) | 23 (79.3%) | < 0.01* |