Changes in dynamic arterial elastance induced by volume expansion and vasopressor in the operating room: a prospective bicentre study

Annals of Intensive Care

Table 3 Random effects models for studying factors associated with temporal evolution of Eadyn, PPV and SVV during fluid challenge

	Eadyn				PPV				SVV
	Baseline effect	p value	Time course effect	p value	Baseline effect	p value	Time course effect	p value	Baseline effect	P value	Time course effect	P value
Arterial load
Intercept	− 1.383	–	–	–	− 17.310	–	–	–	6.989	–	–	–
Age (for 1 year increase)	0.011	0.018*	− 0.007	0.010*	0.168	0.028*	− 0.101	0.023*	0.068	0.468	− 0.044	0.336
Arterial hypertension (yes vs. no)	− 0.301	0.028*	0.156	0.041*	0.899	0.678	− 0.165	0.895	5.781	0.035*	− 2.675	0.046*
Ea (for 1 mmHg/ml increase)	0.799	0.038*	− 0.302	0.156	18.286	0.004*	− 6.048	0.089	11.630	0.130	− 3.035	0.414
Compliance (for 1 ml/mmHg increase)	0.457	0.002*	− 0.205	0.013*	4.976	0.034*	− 2.053	0.128	0.356	0.902	− 0.382	0.786
Resistance (for 1 mmHg/s/ml increase)	− 0.013	0.459	0.005	0.646	− 0.499	0.084	0.189	0.255	− 0.406	0.259	0.105	0.545
Cardiac covariates
Intercept	1.523	–	–	–	25.200	–	–	–	17.112	–	–	–
HR (for 1 beat/min increase)	0.007	0.137	− 0.002	0.356	0.116	0.095	− 0.051	0.203	0.053	0.544	− 0.026	0.544
FTc (for 1 ms increase)	− 0.004	0.032*	0.002	0.107	− 0.016	0.540	0.009	0.525	0.052	0.109	− 0.012	0.436
Stroke volume (for 1 mmHg increase)	0.003	0.334	− 0.002	0.435	− 0.055	0.308	− 0.007	0.826	− 0.100	0.141	− 0.006	0.847
PV	− 0.003	0.386	0.001	0.498	− 0.109	0.052	0.059	0.070	− 0.123	0.078	0.007	0.037*

Results are presented for fully adjusted models with all studied covariates included. p value represents the p value of Wald test for covariate–time interaction estimator
*p value < 0.05 means statistical significance
Ea arterial elastance, FTc corrected aortic flow time, HR heart rate, PV peak velocity of aortic blood flow