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Table 3 Random effects models for studying factors associated with temporal evolution of Eadyn, PPV and SVV during fluid challenge

From: Changes in dynamic arterial elastance induced by volume expansion and vasopressor in the operating room: a prospective bicentre study

  Eadyn PPV SVV
Baseline effect p value Time course effect p value Baseline effect p value Time course effect p value Baseline effect P value Time course effect P value
Arterial load
 Intercept − 1.383 − 17.310 6.989
 Age (for 1 year increase) 0.011 0.018* − 0.007 0.010* 0.168 0.028* − 0.101 0.023* 0.068 0.468 − 0.044 0.336
 Arterial hypertension (yes vs. no) − 0.301 0.028* 0.156 0.041* 0.899 0.678 − 0.165 0.895 5.781 0.035* − 2.675 0.046*
 Ea (for 1 mmHg/ml increase) 0.799 0.038* − 0.302 0.156 18.286 0.004* − 6.048 0.089 11.630 0.130 − 3.035 0.414
 Compliance (for 1 ml/mmHg increase) 0.457 0.002* − 0.205 0.013* 4.976 0.034* − 2.053 0.128 0.356 0.902 − 0.382 0.786
 Resistance (for 1 mmHg/s/ml increase) − 0.013 0.459 0.005 0.646 − 0.499 0.084 0.189 0.255 − 0.406 0.259 0.105 0.545
Cardiac covariates
 Intercept 1.523 25.200 17.112
 HR (for 1 beat/min increase) 0.007 0.137 − 0.002 0.356 0.116 0.095 − 0.051 0.203 0.053 0.544 − 0.026 0.544
 FTc (for 1 ms increase) − 0.004 0.032* 0.002 0.107 − 0.016 0.540 0.009 0.525 0.052 0.109 − 0.012 0.436
 Stroke volume (for 1 mmHg increase) 0.003 0.334 − 0.002 0.435 − 0.055 0.308 − 0.007 0.826 − 0.100 0.141 − 0.006 0.847
 PV − 0.003 0.386 0.001 0.498 − 0.109 0.052 0.059 0.070 − 0.123 0.078 0.007 0.037*
  1. Results are presented for fully adjusted models with all studied covariates included. p value represents the p value of Wald test for covariate–time interaction estimator
  2. *p value < 0.05 means statistical significance
  3. Ea arterial elastance, FTc corrected aortic flow time, HR heart rate, PV peak velocity of aortic blood flow