Changes in dynamic arterial elastance induced by volume expansion and vasopressor in the operating room: a prospective bicentre study

Annals of Intensive Care

Table 4 Random effects models for studying factors associated with temporal evolution of Eadyn, PPV and SVV during neosynephrine infusion

	Eadyn				PPV				SVV
	Baseline effect	p value	Time course effect	p value	Baseline effect	p value	Time course effect	p value	Baseline effect	p value	Time course effect	p value
Arterial load
Intercept	0.320	–	–	–	5.402	–	–	–	0.939	–	–	–
Age (for 1 year increase)	− 0.002	0.761	0.003	0.275	− 0.004	0.933	0.014	0.562	− 0.032	0.722	0.021	0.627
Arterial hypertension (yes vs. no)	0.031	0.856	− 0.052	0.484	0.968	0.453	− 0.611	0.346	2.406	0.331	− 1.172	0.328
Ea (for 1 mmHg/ml increase)	− 0.237	0.704	0.190	0.480	9.265	0.049*	− 0.377	0.871	16.440	0.068	− 1.409	0.744
Compliance (for 1 ml/mmHg increase)	− 0.084	0.647	0.050	0.530	0.421	0.760	0.424	0.539	2.269	0.390	− 0.448	0.725
Resistance (for 1 mmHg/s/ml increase)	− 0.002	0.950	0.002	0.897	− 0.330	0.114	0.070	0.500	− 0.450	0.260	0.019	0.920
Cardiac covariates
Intercept	0.958	–	–	–	14.185	–	–	–	13.030	–	–	–
HR (for 1 beat/min increase)	0.006	0.047*	− 0.001	0.534	0.024	0.607	0.015	0.510	− 0.064	0.490	0.029	0.513
FTc (for 1 ms increase)	− 0.002	0.092	0.001	0.874	0.002	0.913	− 0.005	0.542	0.042	0.200	− 0.001	0.950
Stroke volume (for 1 mmHg increase)	− 0.001	0.927	− 0.002	0.754	− 0.096	0.001*	0.032	0.031*	− 0.135	0.019*	0.024	0.382
PV	0.001	0.780	− 0.001	0.912	0.036	0.147	− 0.021	0.088	0.056	0.249	− 0.043	0.070

Results are presented for fully adjusted models with all studied covariates included. p value represents the p value of Wald test for covariate–time interaction estimator
*p value < 0.05 means statistical significance
Ea arterial elastance, FTc corrected aortic flow time, HR heart rate, PV peak velocity of aortic blood flow