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Table 4 Random effects models for studying factors associated with temporal evolution of Eadyn, PPV and SVV during neosynephrine infusion

From: Changes in dynamic arterial elastance induced by volume expansion and vasopressor in the operating room: a prospective bicentre study

  Eadyn PPV SVV
Baseline effect p value Time course effect p value Baseline effect p value Time course effect p value Baseline effect p value Time course effect p value
Arterial load
 Intercept 0.320 5.402 0.939
 Age (for 1 year increase) − 0.002 0.761 0.003 0.275 − 0.004 0.933 0.014 0.562 − 0.032 0.722 0.021 0.627
 Arterial hypertension (yes vs. no) 0.031 0.856 − 0.052 0.484 0.968 0.453 − 0.611 0.346 2.406 0.331 − 1.172 0.328
 Ea (for 1 mmHg/ml increase) − 0.237 0.704 0.190 0.480 9.265 0.049* − 0.377 0.871 16.440 0.068 − 1.409 0.744
 Compliance (for 1 ml/mmHg increase) − 0.084 0.647 0.050 0.530 0.421 0.760 0.424 0.539 2.269 0.390 − 0.448 0.725
 Resistance (for 1 mmHg/s/ml increase) − 0.002 0.950 0.002 0.897 − 0.330 0.114 0.070 0.500 − 0.450 0.260 0.019 0.920
Cardiac covariates
 Intercept 0.958 14.185 13.030
 HR (for 1 beat/min increase) 0.006 0.047* − 0.001 0.534 0.024 0.607 0.015 0.510 − 0.064 0.490 0.029 0.513
 FTc (for 1 ms increase) − 0.002 0.092 0.001 0.874 0.002 0.913 − 0.005 0.542 0.042 0.200 − 0.001 0.950
 Stroke volume (for 1 mmHg increase) − 0.001 0.927 − 0.002 0.754 − 0.096 0.001* 0.032 0.031* − 0.135 0.019* 0.024 0.382
 PV 0.001 0.780 − 0.001 0.912 0.036 0.147 − 0.021 0.088 0.056 0.249 − 0.043 0.070
  1. Results are presented for fully adjusted models with all studied covariates included. p value represents the p value of Wald test for covariate–time interaction estimator
  2. *p value < 0.05 means statistical significance
  3. Ea arterial elastance, FTc corrected aortic flow time, HR heart rate, PV peak velocity of aortic blood flow