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Table 2 Ventilation parameters and blood gas analysis during postoperative intravenous and VA sedation

From: Use of MIRUS™ for MAC-driven application of isoflurane, sevoflurane, and desflurane in postoperative ICU patients: a randomized controlled trial

  Intravenous propofol sedation Inhalational VA sedation IV vs. VA
Gr. ISO [n = 10] Gr. SEVO [n = 10] Gr. DES [n = 10] All [n = 30] p value ISO [n = 10] SEVO [n = 10] DES [n = 10] All [n = 30] p value p value
Ventilation
 Resp. rate [n] 14.7 [13.2 to 15.5] 13.9 [12.0 to 15.5] 14.1 [13.8 to 16.1] 14.1 [13.7 to 15.5] 0.588 15.3 [14.3 to 17.8] 14.0 [13.3 to 16.0] 15.1 [14.2 to 18.0] 15.1 [13.9 to 16.9] 0.128 0.065
 Tidal vol. [l] 0.58 [0.54 to 0.63] 0.59 [0.54 to 0.64] 0.54 [0.49 to 0.62] 0.59 [0.52 to 0.62] 0.447 0.57 [0.49 to 0.64] 0.62 [0.58 to 0.65] 0.53 [0.48 to 0.63] 0.59 [0.50 to 0.63] 0.385 0.701
 RMV [l min−1] 8.6 [7.3 to 9.2] 8.3 [7.4 to 9.0] 8.4 [7.2 to 8.8] 8.4 [7.4 to 9.0] 0.907 9.2 [7.5 to 10.2] 9.1 [7.7 to 9.5] 9.1 [7.4 to 9.6] 9.2 [7.6 to 9.8] 0.804 0.033 (r = 0.275)
 etCO2 [mmHg] 37.9 [34.09 to 38.73] 34.68 [32.68 to 37.56] 35.94 [32.87 to 39.29] 35.98 [33.13 to 38.72] 0.588 38.0 [37.0 to 40.4] 38.7 [32.5 to 41.9] 37.2 [35.5 to 42.1] 38.0 [35.7 to 41.4] 0.983 0.041 (r = 0.263)
 Pmax [mbar] 20.6 [19.1 to 22.6] 17.9 [14.4 to 20.0] 19.0 [16.4 to 22.3] 19.2 [16.5 to 21.5] 0.069 21.8 [19.7 to 24.4] 18.2 [13.5 to 23.8] 22.1 [20.3 to 23.3] 21.5 [18.3 to 23.8] 0.195 0.056
 PEEP [mbar] 5.8 [5.6 to 7.6] 6.9 [5.2 to 8.6] 5.5 [5.0 to 5.8] 5.7 [5.5 to 7.4] 0.086 6.9 [5.7 to 8.0] 5.8 [3.7 to 8.0] 6.2 [5.2 to 7.4] 6.7 [5.6 to 7.9] 0.460 0.488
BGA
 pH 7.38 [7.33 to 7.42] 7.38 [7.34 to 7.42] 7.39 [7.36 to 7.44] 7.38 [7.35 to 7.43] 0.854 7.45 [7.42 to 7.50] 7.40 [7.39 to 7.42] 7.46 [7.39 to 7.47] 7.43 [7.39 to 7.47] 0.037 *1 0.002
r = 0.396
  *1 ISO vs. DES: p = 0.971; SEVO vs. DES: p = 0.052; ISO vs. SEVO: p= 0.011
 BE [mmol l−1] 1.00 [− 1.30 to 2.68] 0.95 [− 0.73 to 1.88] 2.10 [0.28 to 3.90] 1.45 [− 0.25 to 2.68] 0.452 6.20 [2.53 to 6.75] 4.45 [1.88 to 5.95] 6.00 [4.88 to 9.93] 5.60 [3.23 to 6.73] 0.168 < 0.001
r = 0.572
  1. Ventilation parameters were comparable throughout all groups (Gr.) during propofol and VA sedation. However, the respiratory minute volume (RMV) and the end-tidal expiratory CO2 concentration increased during VA sedation compared to intravenous sedation. Intra- and inter-group comparisons of blood gas analysis (BGA) parameters were not significantly different for hemoglobin (propofol: p = 0.453, VA: p = 0.148; IV vs. VA: p = 0.105), potassium (propofol: p = 0.392, VA: p = 0.309; IV vs. VA: p = 0.628), natrium (propofol: p = 0.402, VA: p = 0.085; IV vs. VA: p = 0.153), and chloride (propofol: p = 0.568, VA: p = 0.361; IV vs. VA: p = 0.830); pH and base excess (BE) increased during VA sedation compared to intravenous sedation. Intragroup comparisons revealed the lowest pH for SEVO during VA sedation
  2. Resp. rate respiratory rate, vol. volume