Table 1 Demographics, comorbidities and clinical features upon admission of patients with necrotizing skin and soft tissue infections before (n = 60), during (n = 35) and after (n = 129) the implementation of a dedicated multimodal and multidisciplinary bundle
Available data | All patients n = 224 | Pre-implementation period (2006–2011) n = 60 | Implementation period (2012–2013) n = 35 | Post-implementation period (2014–2017) n = 129 | p a | |
|---|---|---|---|---|---|---|
Demographics | ||||||
Age, years, median (IQR) | 224 | 64 (53–74) | 66 [55–76] | 68 [60–75] | 61 [53–72] | 0.193 |
Male gender, n (%) | 127 (56.7) | 34 (56.7) | 17 (48.6) | 76 (58.9) | 0.894 | |
Comorbidities, n (%) | ||||||
Diabetes mellitus | 224 | 83 (37.1) | 18 (30.0) | 12 (34.3) | 53 (41.1) | 0.192 |
Immunodeficiency | 58 (25.9) | 13 (21.7) | 14 (40.0) | 31 (24.0) | 0.863 | |
HIV infection | 2 (0.9) | 1 (1.7) | 1 (2.9) | 0 (0.0) | 0.694 | |
Cancer | 21 (9.4) | 5 (8.3) | 7 (20.0) | 9 (7.0) | 0.974 | |
Corticosteroids | 36 (16.1) | 6 (10.0) | 9 (25.7) | 21 (16.3) | 0.355 | |
Obliterating arteritis of the lower limbs | 24 (10.7) | 6 (10.0) | 4 (11.4) | 14 (10.9) | > 0.99 | |
Liver cirrhosis | 9 (4.0) | 1 (1.7) | 2 (5.7) | 6 (4.7) | 0.550 | |
Chronic kidney disease | 25 (11.2) | 7 (11.7) | 5 (14.3) | 13 (10.1) | 0.939 | |
Chronic alcohol consumption | 27 (12.1) | 7 (11.7) | 5 (14.3) | 15 (11.6) | > 0.99 | |
Obesity | 57 (25.4) | 16 (26.7) | 10 (28.6) | 31 (24.0) | 0.834 | |
Prior to admission | ||||||
Time from first symptom, days, median (IQR) | 214 | 5 [2–10] | 6 [2–12] | 4 [1–15] | 5 [3–9] | 0.848 |
Antibiotic treatment, n (%) | 221 | 137 (61.2) | 33 (55.9) | 20 (58.8) | 84 (65.6) | 0.267 |
NSAID use, n (%) | 222 | 46 (20.5) | 9 (15.0) | 4 (11.8) | 33 (26.0) | 0.143 |
Transferred from another center, n (%) | 223 | 116 (51.8) | 31 (51.7) | 16 (47.1) | 69 (53.5) | 0.939 |
Presentation upon admission | ||||||
Nosocomial infection, n (%) | 222 | 45 (20.1) | 20 (33.3) | 8 (23.5) | 17 (13.4) | 0.002 |
Infection site, n (%) | 223 | |||||
Inferior limbs | 173 (77.2) | 40 (66.7) | 30 (85.7) | 103 (80.5) | 0.060 | |
Superior limbs | 19 (8.5) | 8 (13.3) | 1 (2.9) | 10 (7.8) | 0.351 | |
Abdomino-perineal infection | 38 (17.0) | 13 (21.7) | 4 (11.4) | 21 (16.4) | 0.503 | |
Cervico-facial infection | 2 (0.9) | 0 (0.0) | 0 (0.0) | 2 (1.6) | 0.833 | |
Other | 1 (0.4) | 0 (0.0) | 0 (0.0) | 1 (0.8) | 1 | |
Multifocal infection, n (%) | 223 | 23 (10.3) | 5 (8.3) | 4 (11.4) | 14 (10.9) | 0.770 |
Shock, n (%) | 220 | 91 (40.6) | 30 (50.8) | 12 (34.3) | 49 (38.9) | 0.170 |