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Table 2 ROC analyses for prediction of mortality according to baseline (< 24 h of admission) biomarker concentration

From: Prediction of mortality in adult patients with sepsis using six biomarkers: a systematic review and meta-analysis

StudyMortality follow-upAUC (95% CI)CutoffSnSpPPVNPVLR+LR−
Angiopoietins 1 and 2
 Ang-2/Ang-1 ratio
  Fang [30]28 days0.845 (0.810 to 0.880)1.9480%81%78%83%3.980.31
 Ang-1
  Ricciuto [36]28 days0.620 (0.500 to 0.760)
  Lin [32]During hospital stay0.743 (0.726 to 0.847)
  Fang [30]28 days0.778 (0.732 to 0.824)
 Ang-2
  Lin [32]During hospital stay0.632 (0.515 to 0.750)
  Kranidioti [31]28 days0.703 (0.578 to 0.827)9700 pg/ml42%82%51%76%2.320.49
  van der Heijden [38]ICU mortality0.7903066 pg/ml73%71%39%91%2.520.38
  Fang [30]28 days0.794 (0.750 to 0.837)
  Palud [34]28 days0.960 (0.870 to 1.050)26,780 pg/ml100%93%83%100%14.290
HMGB1
 Karlsson [42]During hospital stay0.570 (0.470 to 0.670)6.5 ng/ml39%79%40%79%1.870.77
 Gibot [40]28 days0.610
sRAGE
 Bopp [50]28 days1569 pg/ml85%75%73%86%3.380.21
 Brodska [51]28 days0.660 (0.492 to 0.827)1804 pg/ml63%76%53%83%2.640.49
sTREM-1
 Bayram [60]not specified0.444255 pg/ml50%40%50%40%0.831.25
 Suarez-Santamaria [56]28 days0.598 (0.520 to 0.676)55.7 pg/ml68%58%31%87%1.620.55
 Charles [61]ICU mortality0.640 (0.540 to 0.740)954 pg/ml55%78%49%82%2.480.58
 Ravetti [47]28 days0.640 (0.460 to 0.830)750 pg/ml56%68%60%65%1.750.65
 Ravetti [47]ICU mortality0.690 (0.510 to 0.870)750 pg/ml56%75%60%72%2.240.59
 Gibot [53]28 days0.740 (0.680 to 0.800)180 pg/ml86%70%59%91%2.870.20
 Su [58]28 days0.748 (0.637 to 0.860)0.49963%84%81%54%4.010.43
 Brenner [62]90 days0.827521 pg/ml71%86%87%79%4.990.33
 Li [59]28 days0.856 (0.784 to 0.929)252 pg/ml86%76%71%88%3.530.19
suPAR
 Suberviola [66]During hospital stay0.670 (0.570 to 0.770)9.6 ng/ml81%46%39%85%1.490.43
 Giamarellos-Bourboulis [63]28 days0.708 (0.681 to 0.736)12.0 ng/ml62%69%36%87%1.990.55
 Khater [68]30 days0.720 (0.560 to 0.853)6.3 ng/ml79%63%76%67%2.110.33
 Donadello [67]ICU and 28 days0.72310.2 ng/ml71%65%38%88%2.030.45
 Zeng [72]28 days0.765 (0.658 to 0.872)12.0 ng/ml87%73%66%90%3.170.18
 Shan [70]90 days0.780 (0.630 to 0.930)310 pg/ml69%65%
 Tsirigotis [71]28 days0.7877.6 ng/ml82%73%63%88%3.040.25
 Liu [69]28 days0.788 (0.73 to 0.846)10.8 ng/ml85%78%39%97%3.790.19
  1. ICU intensive care unit, ROC receiver operating characteristic, AUC area under the curve, Sn sensitivity, Sp specificity, PPV positive predictive value, NPV negative predictive value, LR+ positive likelihood ratio, LR− negative likelihood ratio