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Table 2 Comparison between three hyperlactatemia groups

From: Targeted temperature management guided by the severity of hyperlactatemia for out-of-hospital cardiac arrest patients: a post hoc analysis of a nationwide, multicenter prospective registry

VariablesHyperlactatemia classificationp value
Mild
n = 139
Moderate
n = 182
Severe
n = 114
Age, years64 [52, 73]64 [50, 75]60 [48, 68]0.087
Age > 65 years63 (45)81 (45)38 (33)0.098
Male sex105 (76)143 (79)90 (79)0.757
Witness118 (85)149 (82)81 (71)0.017
Dispatcher instruction66 (47)89 (49)43 (38)0.149
Bystander-performed CPR77 (55)100 (55)51 (45)0.161
Cardiac etiology115 (83)135 (74)82 (72)0.089
Initial shockable rhythm88 (63)100 (55)47 (41)0.002
Prehospital epinephrine administration21 (15)41 (23)37 (32)0.005
Prehospital advanced airway management33 (24)61 (34)51 (45)0.002
Prehospital AED114 (82)132 (73)67 (59)< 0.001
Response time, min8 [6, 9]8 [6, 9]8 [7, 9]0.376
Time from call to hospital arrival, min32 [25, 39]30 [24, 35]29 [24, 37]0.200
Prehospital ROSC102 (73)112 (62)38 (33)< 0.001
Glasgow Coma Scale score3 [3, 4]3 [3, 3]3 [3, 3]< 0.001
Coronary angiography85 (61)106 (58)66 (58)0.833
ECMO and/or IABP45 (32)37 (20)41 (36)0.006
Door-to-first ABG measurement after ROSC, min11 [5, 30]9 [5, 18]15 [7, 30]0.007
pH7.28 [7.22, 7.33]7.12 [7.02, 7.28]6.92 [6.75, 7.03]< 0.001
PaCO2, mm Hg43 [37, 51]52 [35, 75]70 [43, 97]< 0.001
PaCO2 30–50 mm Hg90 (65)63 (35)27 (24)< 0.001
PaO2, mm Hg176 [91, 337]187 [92, 356]150 [79, 346]0.760
HCO3, mmol/l19.9 [17.1, 21.7]16.4 [13.9, 18.6]12.9 [10.3, 16.8]< 0.001
Base excess, mmol/l− 6.2 [− 9.1, − 4.0]− 12 [− 14.7, − 9.5]− 19.4 [− 24.1, − 15.4]< 0.001
Lactate value, mmol/l5.2 [3.7, 6.1]9.1 [7.9, 10.2]14.9 [13.2, 18.0]< 0.001
Door-to-TTM initiation, min106 [30, 188]115 [36, 190]136 [46, 225]0.324
Targeted temperature management   0.331
 32–34 °C108 (78)128 (70)83 (73) 
 35–36 °C31 (22)54 (30)31 (27) 
30-day favorable neurological outcome84 (60)76 (42)22 (19)< 0.001
30-day survival117 (84)144 (79)64 (56)< 0.001
  1. Continuous variables were presented as median [Interquartile range]. Categorical variables were presented as n (%)
  2. CPR cardiopulmonary resuscitation, AED automated external defibrillator, ROSC return of spontaneous circulation, ECMO extracorporeal membrane oxygenation, IABP intra-aortic balloon pumping, ABG arterial blood gas