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Table 3 Comparison between 32–34 and 35–36 °C in each hyperlactatemia group

From: Targeted temperature management guided by the severity of hyperlactatemia for out-of-hospital cardiac arrest patients: a post hoc analysis of a nationwide, multicenter prospective registry

VariablesMild hyperlactatemiap valueModerate hyperlactatemiap valueSevere hyperlactatemiap value
32–34 °C
n = 108
35–36 °C
n = 31
32–34 °C
n = 128
35–36 °C
n = 54
32–34 °C
n = 83
35–36 °C
n = 31
Age, years64 [52, 72]66 [54, 79]0.10562 [50, 74]71 [51, 80]0.03658 [47, 67]64 [55, 71]0.112
Age > 65 years47 (43.5)16 (51.6)0.54050 (39)31 (57)0.03324 (28.9)14 (45.2)0.121
Male sex80 (74)25 (81)0.636101 (79)42 (78)0.84667 (81)23 (74)0.449
Witness92 (85)26 (84)0.784106 (83)43 (80)0.67561 (74)20 (65)0.361
Dispatcher instruction48 (44)18 (58)0.22263 (49)26 (48)1.00031 (37)12 (39)1.000
Bystander-performed CPR58 (54)19 (61)0.54073 (57)27 (50)0.41739 (47)12 (39)0.527
Cardiac etiology90 (83)25 (81)0.78898 (77)37 (69)0.27161 (74)21 (68)0.640
Initial shockable rhythm74 (69)14 (45)0.02175 (59)25 (46)0.14436 (43)11 (36)0.524
Prehospital epinephrine administration18 (17)3 (10)0.40931 (24)10 (19)0.44427 (33)10 (32)1.000
Prehospital advanced airway management24 (22)9 (29)0.47541 (32)20 (37)0.60637 (45)14 (45)1.000
Prehospital AED90 (83)24 (77)0.43793 (73)39 (72)1.00050 (60)17 (55)0.671
Response time, min8 [6, 9]8 [6, 10]0.7497 [6, 9]8 [6, 9]0.3818 [6, 9]8 [7, 11]0.329
Time from call to hospital arrival, min32 [25, 40]31 [23, 33]0.28330 [24, 34]31 [24, 36]0.54229 [25, 37]28 [24, 39]0.769
Prehospital ROSC77 (71)25 (81)0.36278 (61)34 (63)0.86831 (37)7 (23)0.181
Glasgow Coma Scale score3 [3, 3]3 [3, 6]0.0973 [3, 3]3 [3, 3]0.6023 [3, 3]3 [3, 3]0.856
Coronary angiography66 (61)19 (61)1.00078 (61)28 (52)0.32452 (63)14 (45)0.135
ECMO and/or IABP37 (34.3)8 (25.8)0.51450 (39)13 (24)0.06132 (39)9 (29)0.388
Door-to-first ABG measurement after ROSC, min11 [5, 32]9 [5, 22]0.30010 [5, 17]9 [6, 18]0.78413 [6, 30]19 [11, 35]0.056
pH7.28 [7.22, 7.32]7.31 [7.20, 7.37]0.1077.14 [7.02, 7.28]7.08 [7.01, 7.25]0.3566.92 [6.81, 7.03]6.91 [6.74, 7.15]0.817
PaCO2, mm Hg43 [38, 51]40 [33, 51]0.31847 [34, 75]60 [36, 75]0.20069 [44, 90]72 [31, 108]0.873
PaCO2 30–50 mm Hg71 (65.7)19 (61.3)0.67450 (39)13 (24)0.06123 (28)4 (13)0.137
PaO2, mm Hg170 [91, 350]176 [93, 325]0.975179 [86, 354]195 [113, 350]0.449148 [76, 345]240 [86, 363]0.437
HCO3, mmol/l20.0 [16.8, 21.5]19.9 [18.0, 22.8]0.60816.3 [13.9, 18.5]16.6 [13.6, 19.5]0.47113.0 [10.4, 17.1]12.7 [10.3, 15.1]0.530
Base excess, mmol/l− 6.4 [− 9.3, − 4.0]− 5.7 [− 7.3, − 4.1]0.369− 11.9 [− 14.9, − 9.4]− 12.5 [− 14.0, − 9.9]0.905− 19.6 [− 23.7, − 16.2]− 19.4 [− 24.5, − 12.6]0.703
Lactate value, mmol/l5.1 [3.6, 6, 1]5.4 [3.9, 6.5]0.1859.1 [7.9, 10.1]9.3 [8.1, 10.6]0.77514.7 [13.1, 17.3]16.2 [14.0, 19.4]0.113
Door-to-TTM initiation, min82 [20, 174]167 [109, 213]0.00378 [21, 170]164 [103., 218]< 0.001105 [35, 202]198 [109, 261]0.002
30-day favorable neurological outcome65 (60)19 (61)1.00056 (44)20 (37)0.41718 (22)4 (13)0.425
30-day survival89 (82)28 (90)0.406100 (78)44 (82)0.69348 (58)16 (52)0.672
  1. Continuous variables were presented as median [Interquartile range]. Categorical variables were presented as n (%)
  2. CPR cardiopulmonary resuscitation, AED automated external defibrillator, ROSC return of spontaneous circulation, ECMO extracorporeal membrane oxygenation, IABP intra-aortic balloon pumping, ABG arterial blood gas