IgM-enriched immunoglobulins (Pentaglobin) may improve the microcirculation in sepsis: a pilot randomized trial

Annals of Intensive Care

Table 1 Baseline characteristics

Patient demographics	Pentaglobin (n = 10)	Placebo (n = 9)	p
Age (years)	62 ± 20	67 ± 16	0.545
Gender (nr of males, %)	7 (70%)	8 (89%)	0.582
Comorbidities (n, %)			0.659
Arterial hypertension	4 (40%)	3 (33%)
Cardiopathy	1 (10%)	1 (11%)
Diabetes	2 (20%)	1 (11%)
Malignancy	3 (30%)	2 (22%)
SAPS II (admission)	42 ± 17	45 ± 12	0.690
APACHE II (admission)	17 ± 8	21 ± 7	0.243
SOFA (admission)	9 ± 4	10 ± 3	0.663
Source of sepsis (n, %)			0.532
Abdominal	4 (40%)	2 (22%)
Pulmonary	3 (30%)	2 (22%)
Uro-genital	1 (10%)	3 (33%)
Soft tissues	1 (10%)	2 (22%)
Other	1 (10%)	0 (0%)
Multi-drug-resistant pathogen (n, %)	4 (40%)	5 (56%)	0.656
Shock^a (n, %)	3 (30%)	2 (22%)	0.999

SAPS Simplified Acute Physiology Score, APACHE Acute Physiology and Chronic Health Evaluation, SOFA Sequential Organ Failure Assessment
^aPersistent arterial hypotension despite adequate fluid resuscitation and hyperlactatemia (lactate levels > 2 mmol/L)