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Annals of Intensive Care

Table 3 Diagnostic ability of the changes in haemodynamic variables to diagnose a fluid-induced increase in cardiac output ≥ 15%

From: How to detect a positive response to a fluid bolus when cardiac output is not measured?

 

r vs. changes in CO

p value for the correlation

Sensitivity

Specificity

Positive PV

Negative PV

Positive LR

Negative LR

Best threshold

AUROC

p value for AUROC vs. 0.50

n

Decrease in HR (in %)

–

0.06

49 (43–55)

57 (50–64)

59 (54–63)

47 (43–54)

1.1 (0.9–1.4)

0.9 (0.8–1.1)

< − 2%

0.529 ± 0.026*

0.27

479

Increase in SAP (in %)

0.38

< 0.0001

65 (58–70)

66 (66–73)

71 (66–75)

60 (55–64)

1.9 (1.6–2.4)

0.5 (0.4–0.6)

> 9%

0.697 ± 0.024

< 0.001

482

Increase in MAP (in %)

0.33

< 0.0001

58 (52–64)

70 (63–76)

71 (66–75)

57 (53–61)

1.9 (1.5–2.4)

0.6 (0.5–0.7)

> 8%

0.654 ± 0.026*

< 0.001

484

Increase in DAP (in %)

–

0.84

53 (46–60)

52 (45–59)

54 (49–58)

51 (46–56)

1.1 (0.9–1.3)

0.9 (0.7–1.1)

> 31%

0.509 ± 0.029*

0.77

410

Decrease in shock index (in %)

− 0.35

< 0.0001

66 (60–72)

64 (57–70)

70 (66–74)

60 (55–64)

2.0 (1.6–2.4)

0.5 (0.4–0.6)

< − 9%

0.688 ± 0.024

< 0.001

479

Increase in PP/HR ratio (in %)

0.33

< 0.0001

52 (46–58)

79 (72–83)

76 (70–80)

56 (52–59)

2.4 (1.8–3.2)

0.6 (0.5–0.7)

> 41%

0.668 ± 0.024

< 0.001

479

Increase in PP (in %)

0.38

< 0.0001

72 (66–77)

64 (57–70)

71 (67–75)

65 (60–70)

1.8 (1.5–2.2)

0.4 (0.4–0.5)

> 10%

0.719 ± 0.023

< 0.001

478

Decrease in PPV (in abs val) (all)

− 0.24*

< 0.0001

64 (57–71)

63 (54–70)

70 (64–74)

57 (52–63)

1.7 (1.4–2.2)

6.0 (0.5–0.7)

< − 2 points

0.663 ± 0.028*

< 0.001

357

Decrease in PPV (in abs val) (without arrhythmia, spontaneous breathing, and ARDS)

− 0.24*

< 0.0001

48 (28–69)

100 (73–100)

100 (75–100)

48 (39–57)

–

1.0 (1.0–1.0)

< − 7 points

0.750 ± 0.080

< 0.001

37

Decrease in PPV (in abs val) (without arrhythmia and spontaneous breathing)

0.56

< 0.0001

33 (23–44)

86 (77–93)

74 (59–84)

54 (50–58)

2.5 (1.3–4.9)

0.8 (0.6–0.9)

< − 8 points

0.532 ± 0.045

0.48

160

  1. AUROC area under the receiver operating characteristic curve, CO cardiac output, DAP diastolic arterial pressure, HR heart rate, LR likelihood ratio, MAP mean arterial pressure, n number of patients included in the analysis after exclusion of outliers, PP pulse pressure, PPV pulse pressure variation, PV predictive value, SAP systolic arterial pressure, Vt tidal volume
  2. * p < 0.05 vs. results obtained for changes in PP (in %). Values are expressed as mean ± standard deviation or mean (95% confidence interval)
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