TY - JOUR AU - Kothekar, Amol T. AU - Divatia, Jigeeshu Vasishtha AU - Myatra, Sheila Nainan AU - Patil, Anand AU - Nookala Krishnamurthy, Manjunath AU - Maheshwarappa, Harish Mallapura AU - Siddiqui, Suhail Sarwar AU - Gurjar, Murari AU - Biswas, Sanjay AU - Gota, Vikram PY - 2020 DA - 2020/01/10 TI - Clinical pharmacokinetics of 3-h extended infusion of meropenem in adult patients with severe sepsis and septic shock: implications for empirical therapy against Gram-negative bacteria JO - Annals of Intensive Care SP - 4 VL - 10 IS - 1 AB - Optimal anti-bacterial activity of meropenem requires maintenance of its plasma concentration (Cp) above the minimum inhibitory concentration (MIC) of the pathogen for at least 40% of the dosing interval (fT > MIC > 40). We aimed to determine whether a 3-h extended infusion (EI) of meropenem achieves fT > MIC > 40 on the first and third days of therapy in patients with severe sepsis or septic shock. We also simulated the performance of the EI with respect to other pharmacokinetic (PK) targets such as fT > 4 × MIC > 40, fT > MIC = 100, and fT > 4 × MIC = 100. SN - 2110-5820 UR - https://doi.org/10.1186/s13613-019-0622-8 DO - 10.1186/s13613-019-0622-8 ID - Kothekar2020 ER -