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Table 1 Patient characteristics

From: Clinical pharmacokinetics of 3-h extended infusion of meropenem in adult patients with severe sepsis and septic shock: implications for empirical therapy against Gram-negative bacteria

ParametersValue
Age (years) median (range)54 (25–70)
Gender
 Male12
 Female13
APACHE score (mean ± SD)15.4 ± 8.09
Mean SOFA score (mean ± SD)
 Day 17.35 ± 3.62
 Day 36.07 ± 2.09
Baseline albumin level (g/dL)2.35 ± 0.8
Baseline serum creatinine (mg/dL)a
 Median0.9
 Range0.5–2.6
Baseline creatinine clearance
(mL/min) (mean ± SD)
73.8 ± 26.6
Requirement of mechanical ventilation (n,  %)22 (88%)
Requirement of inotropes (n,  %)15 (60%)
Median ICU length of stay (IQR)8 days (5–14)
ICU mortality, n (%)10 (40%)
Hospital mortality, n (%)11 (44%)
  1. APACHE II Acute Physiology and Chronic Health Evaluation II, ICU intensive care unit, IQR inter-quartile range, SD standard deviation, SOFA Score: Sequential Organ Failure Assessment Score
  2. aPredicted creatinine clearance calculated based on formula discovered by Cockcroft and Gault